Browsing by Author "Castelnuovo, Barbara"
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Baseline severe anaemia should not preclude use of zidovudine in antiretroviral-eligible patients in resource-limited settings
Kiragga, Agnes N; Castelnuovo, Barbara; Nakanjako, Damalie; Manabe, Yukari C (BioMed Central, 2010)Background: Stavudine is no longer recommended as part of first-line therapy for patients initiating antiretroviral therapy (ART) in Uganda. Most patients are currently initiated on zidovudine-containing regimens, which ... -
Belief in divine healing can be a barrier to antiretroviral therapy adherence in Uganda
Wanyama, Jane; Castelnuovo, Barbara; Wandera, Bonnie; Mwebaze, Patricia; Kambugu, Andrew; Bangsberg, David R.; Kamya, Moses R. (Lippincott Williams & Wilkins., 2007)Although recent data suggest high levels of adherence to expanding antiretroviral therapy (ART) programmes in resource-limited settings, the culture- specific barriers to adherence are poorly understood. In a prospective ... -
Bilateral pedal edema in an HIV patient: Lopinavir/Ritonavir-containing treatment regimen as a potential cause?
Shihab, Hasan M; Lutwama, Fred; Piloya, Theresa; Castelnuovo, Barbara; Kambugu, Andrew D.; Colebunders, Robert (Open Learning on Enteric Pathogens, 2009-03)A large number of patients are switched to second-line antiretroviral therapy, especially in resource limited settings. Lopinavir/Ritonavir is the main drug used in second-line treatment regimens. We describe a patient ... -
Can response of a pruritic papular eruption to antiretroviral therapy be used as a clinical parameter to monitor virological outcome?
Castelnuovo, Barbara; Byakwaga, Hellen; Menten, Joris; Schaefer, Petra; Kamya, Moses; Colebunders, Robert (Lippincott Williams & Wilkins, 2008)Background: A pruritic papular eruption (PPE) is a common skin manifestation observed in 12–46% of persons with HIV infection living in tropical countries. Objective: To determine whether PPE responds to HAART and whether ... -
Cause-Specific Mortality and the Contribution of Immune Reconstitution Inflammatory Syndrome in the First 3 Years after Antiretroviral Therapy Initiation in an Urban African Cohort
Castelnuovo, Barbara; Manabe, Yukari C; Kiragga, Agnes; Kamya, Moses; Easterbrook, Philippa; Kambugu, Andrew (Infectious Diseases Society of America, 2009)Background. Although many studies have reported high early mortality among patients enrolled in antiretroviral therapy (ART) programs in sub-Saharan Africa—particularly among those individuals with advanced immunodeficiency— ... -
Cost Effectiveness of a Pharmacy-Only Refill Program in a Large Urban HIV/AIDS Clinic in Uganda
Babigumira, Joseph B; Castelnuovo, Barbara; Stergachis, Andy; Kiragga, Agnes; Shaefer, Petra; Lamorde, Mohammed; Kambugu, Andrew; Muwanga, Alice; Garrison, Louis P. (Public Library of Science, 2011-03-28)Background: HIV/AIDS clinics in Uganda and other low-income countries face increasing numbers of patients and workforce shortages. We performed a cost-effectiveness analysis comparing a Pharmacy-only Refill Program (PRP), ... -
Efficacy and safety of dolutegravir or darunavir in combination with lamivudine plus either zidovudine or tenofovir for second-line treatment of HIV infection (NADIA): week 96 results from a prospective, multicentre, open-label, factorial, randomised, non-inferiority trial
Paton, Nichilas I.; Musaazi, Joseph; Kityo, Cissy; Walimbwa, Stephen; Hoppe, Anne; Balyegisawa, Apolo; Asienzo, Jesca; Kaimal, Arvind; Mirembe, Grace; Lugemwa, Abbas; Ategeka, Gilbert; Borok, Margaret; Mugerwa, Henry; Siika, Abraham; Odongpiny, Eva Laker A.; Castelnuovo, Barbara; Kiragga, Agnes; Kambugu, Andrew (Elsevier, 2022-04-20)Background WHO guidelines recommend dolutegravir plus two nucleoside reverse transcriptase inhibitors (NRTIs) for second-line HIV therapy, with NRTI switching from first-line tenofovir to zidovudine. We aimed to ... -
Evaluation of portable point-of-care CD4 counter with high sensitivity for detecting patients eligible for antiretroviral therapy
Manabe, Yukari C.; Wang, Yaping; Elbireer, Ali; Auerbach, Brandon; Castelnuovo, Barbara (Public Library of Science, 2012-04-19)Background: Accurate, inexpensive point-of-care CD4+ T cell testing technologies are needed that can deliver CD4+ T cell results at lower level health centers or community outreach voluntary counseling and testing. We ... -
Free antiretrovirals must not be restricted only to treatment-naive patients: experience in Uganda suggests that restricting access is not the way forward
Colebunders, Robert; Kamya, Moses; Semitala, Fred; Castelnuovo, Barbara; Katabira, Elly; McAdam, Keith (Public Library of Science, 2005-10)No Abstract -
HIV Eosinophilic Folliculitis in Uganda
Colebunders, Robert; Castelnuovo, Barbara; Byakwaga, Hellen (American Medical Association (AMA), 2006) -
Improvement of the patient flow in a large urban clinic with high HIV seroprevalence in Kampala, Uganda
Castelnuovo, Barbara; Babigumira, Joyce; Lamorde, M.; Muwanga, A.; Kambugu, A.; Colebunders, R. (International Journal of STD & AIDS, 2009)Antiretroviral treatment roll-out programmes in Africa often have difficulties to cope with the increasing number of clients. Based on the findings of a survey carried out in 2005 that showed long waiting times, innovative ... -
Integration of HIV and TB services results in improved TB treatment outcomes and earlier prioritized ART initiation in a large urban HIV clinic in Uganda
Hermans, Sabine M.; Castelnuovo, Barbara; Katabira, Catherine; Mbidde, Peter; Lange, Joep M. A.; Hoepelman, Andy I. M.; Coutinho, Alex; Manabe, Yukari C. (Lippincott, Williams & Wilkins, 2012-06-01)Background: The World Health Organization recommends that treatment of tuberculosis ... -
Is it safe to switch from stavudine to zidovudine after developing symptomatic hyperlactatemia?
Castelnuovo, Barbara; Nanyonjo, Agnes; Kamya, Moses; Ocama, Ponsiano (African Health Sciences, 2008-06)Introduction: In resource limited settings patients on antiretroviral treatment who develop stavudine induced hyperlactatemia are often switched to zidovudine on the basis of published studies that demonstrate that this ... -
Longitudinal patients’ cohorts for impactful research and HIV care at the Infectious Diseases Institute
Castelnuovo, Barbara; Kamya, Moses; Ratanshi, Rosalind Parkes; Kiragga, Agnes N.; Nakanjako, Damalie (2022)Introduction Observational studies provide important evidence supporting the feasibility and effectiveness of health interventions. The 20-year-old Infectious Diseases Institute (IDI) established to respond to infectious ... -
Plasmodium falciparum genetic diversity and multiplicity of infection based on msp‑1, msp‑2, glurp and microsatellite genetic markers in Sub-Saharan Africa: a systematic review and meta-analysis
Mwesigwa, Alex; Ocan, Moses; Musinguzi, Benson; Nante, Rachel, W; Nankabirwa, Joaniter, I; Kiwuwa, Steven, M.; Kinengyere, Alison, A.; Castelnuovo, Barbara; Karamagi, Charles; Obuku, Ekwaro, A.; Nsobya, Samuel, L.; Mbulaiteye, Sam, M.; Kibwika, Pauline, B. (BMC, 2024)Background In sub-Saharan Africa (SSA), Plasmodium falciparum causes most of the malaria cases. Despite its crucial roles in disease severity and drug resistance, comprehensive data on Plasmodium falciparum genetic ... -
Potential impact of task-shifting on costs of antiretroviral therapy and physician supply in Uganda
Babigumira, Joseph B; Castelnuovo, Barbara; Lamorde, Mohammed; Kambugu, Andrew; Stergachis, Andy; Easterbrook, Philippa; Garisson, Louis P. (BMC Health Services Research, 2009-01-09)Background Lower-income countries face severe health worker shortages. Recent evidence suggests that this problem can be mitigated by task-shifting—delegation of aspects of health care to less specialized health workers. ... -
Quality of data collection in a large HIV observational clinic database in sub-Saharan Africa: implications for clinical research and audit of care
Kiragga, Agnes N; Castelnuovo, Barbara; Schaefer, Petra; Muwonge, Timothy; Easterbrook, Philippa J (BioMed Central, 2011)Background: Observational HIV clinic databases are now widely used to answer key questions related to HIV care and treatment, but there has been no systematic evaluation of their quality of data. Our objective was to ... -
A Randomized controlled trial to evaluate the effectiveness of a board game on patients' knowledge uptake of HIV and sexually transmitted diseases at the Infectious Diseases Institute, Kampala, Uganda
Wanyama, Jane N; Castelnuovo, Barbara; Robertson, Gavin; Newell, Kevin; Sempa, Joseph B; Kambugu, Andrew; Manabe, Yuka C.; Colebunders, Robert (JAIDS Journal of Acquired Immune Deficiency Syndromes, 2012-03-01)Background: As the number of HIV infections continues to rise, the search for effective health education strategies must intensify. A new educational board game was developed to increase HIV peoples' attention and knowledge ... -
Rifampicin for continuation phase tuberculosis treatment in Uganda: a cost-effectiveness analysis
Manabe, Yukari C.; Hermans, Sabine M.; Lamorde, Mohammed; Castelnuovo, Barbara; Mullins, C. Daniel; Kuznik, Andreas (Public Library of Science, 2012-06)Background: In Uganda, isoniazid plus ethambutol is used for 6 months (6HE) during the continuation treatment phase of new tuberculosis (TB) cases. However, the World Health Organization (WHO) recommends using isoniazid ... -
Sub-optimal CD4 reconstitution despite viral suppression in an urban cohort on Antiretroviral Therapy (ART) in sub-Saharan Africa: Frequency and clinical significance
Nakanjako, Damalie; Kiragga, Agnes; Ibrahim, Fowzia; Castelnuovo, Barbara; Kamya, Moses R.; Easterbrook, Philippa J. (BioMed Central, 2008-10)Background: A proportion of individuals who start antiretroviral therapy (ART) fail to achieve adequate CD4 cell reconstitution despite sustained viral suppression. We determined the frequency and clinical significance of ...