Browsing by Subject "Ugandans"
Now showing items 1-6 of 6
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Genetic determinants of differential susceptibility to hepatitis B Infection among a general population cohort from southwestern Uganda: a genome-wide association study
(Makerere University, 2023-11)Introduction: Hepatitis B is one of the major causes of mortality and morbidity worldwide. Hepatitis B infection causes liver inflammation and damage that may progress to liver cirrhosis, liver cancer and ultimately lead ... -
Genetic variations in ABCB1 and CYP3A5 as well as sex influence quinine disposition among Ugandans
(Lippincott Wilkins & Williams, 2010)Abstract: Quinine is one of the most effective antimalarial drugs, although its clinical use is limited as a result of its narrow safety margin. Quinine is a substrate of the polymorphic p-glycoprotein and CYP3A4/3A5. This ... -
Genotypic and phenotypic characterization of HIV-1 transmitted/founder viruses and their effect on cytokine profiles and disease progression among acutely infected Ugandans
(Makerere University, 2022)Virus-host interaction early after transmission elicit changes that are known to impact the course of the infection and clinical outcome. The nature of the virus that initiates the infection seems to play a key role. For ... -
Monocyte activation and dysregulation in treated and untreated hiv-1 infected Ugandans.
(Makerere University, 2018-08-30)Introduction: Mechanism for increased non-AIDs co morbidities in HIV-1infected individuals on combinatorial antiretroviral therapy (cART) still requires exploration. This is majorly attributed to chronic monocyte activation ... -
A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans
(The British Pharmacological Society, 2009)AIMS Efavirenz exhibits pharmacokinetic variability causing varied clinical response. The aim was to develop an integrated population pharmacokinetic/pharmacogenetic model and investigate the impact of genetic variations, ... -
A novle polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single dose efavirenz population pharmacokinetics in Ugandans
(Wiley-Blackwell, 2009)AIMS Efavirenz exhibits pharmacokinetic variability causing varied clinical response. The aim was to develop an integrated population pharmacokinetic/pharmacogenetic model and investigate the impact of genetic variations, ...