Browsing School of Bio-Medical Sciences (Bio-Medical) Collections by Author "Ashton, Michael"
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HIV/AIDS patients display lower relative bioavailability of Efavirenz than healthy subjects
Mukonzo, Jackson K; Nanzigu, Sara; Rekic, Dinko; Waako, Paul; Roshammar, Daniel; Ashton, Michael; Ogwal-Okeng, Jasper; Gustafsson, Lars L.; Aklillu, Eleni (Adis Data Information BV., 2011)Background: Pharmacokinetic studies of antiretroviral drugs are often conducted in adult healthy subjects, and the results are extrapolated to HIV/AIDS patients. HIV/AIDS, however, is known to cause morphological and ... -
In silico prediction of efavirenz and rifampicin drug–drug interaction considering weight and CYP2B6 phenotype
Rekic´, Dinko; Röshammar, Daniel; Mukonzo, Jackson K; Ashton, Michael (The British Pharmacological Society, 2010)AIMS This study aimed to test whether a pharmacokinetic simulation model could extrapolate nonclinical drug data to predict human efavirenz exposure after single and continuous dosing as well as the effects of concomitant ...