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Significance of minority HIV-1 X-4-tropic variants, Host CCR5 promoter genotype in predicting paediatric Virological failure
(Makerere University, 2019-11-04)
Background
By Sept 2018, only 59.3% of all HIV positive children on cART under 5 years were achieving virological suppression compared to 88.4% in the general population in Uganda. However, while its known that a tropism ...
Barriers to partner HIV serostatus disclosure among postnatal mothers on option b+ in Rukungiri district
(Makerere University, 2019-12-02)
Introduction; Self-disclosure of one’s positive HIV serostatus to partners is an important step in the pathway of transmission prevention through sexual risk reduction and uptake of treatment and support services. Disclosure ...
Prevalence of staphylococcus aureus isolated from the lower genital tract of mothers in labour possessing selected virulence factor genes in Uganda.
(Makerere University, 2019-11-28)
Background: Staphylococcus aureus is one of the gram positive bacteria colonizing the human body. It colonizes in approximately one third of the general population worldwide. It particularly colonizes the skin, nasal ...
Social networks in gross anatomy dissection room and students' performance at Makerere University College of Health Sciences
(Makerere University, 2019-09-23)
Introduction: Social interactions between students in the gross anatomy dissection room are a major and underexplored part of undergraduate education. Yet understanding how learning relationships form inside the dissection ...
Nasopharyngeal co-colonization and drug resistance patterns of potentially pathogenic bacteria in children attending Mulago assessment centre Pediatric Unit of Mulago National Referral Hospital, Uganda
(Makerere University, 2019-10)
Background: The human nasopharynx is colonized by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and Staphylococcus aureus. These bacteria may cause several diseases, especially in young children. ...
Human B and T cell responses to novel Schistosoma mansoni skin-stage antigens
(2019-10)
Background
Larvae of Schistosoma (schistosomula) are highly susceptible to host immune responses and are attractive prophylactic vaccine targets. Despite this, cellular and humoral immune responses against schistosomula ...
DEVELOPMENT AND OPTIMIZATION OF AN IN VITRO METHOD TO FORCE AND SELECT FOR FUNCTIONAL HIV-1 INTERSUBTYPE pol RECOMBINANTS
(Makerere University, 2019-10-22)
Introduction
Inter subtype recombination in the pol gene of the HIV-1 affects the enzymatic structure and
integrity which greatly impacts their function. These may be silent, deleterious or beneficial for
the survival ...
Maternal transfer of immunoglobulin-g (igg) sub-types and its association to immunity against plasmodium falciparum infection among children in a Ugandan birth cohort (Busia-Eastern Uganda)
(2019-11-04)
Background: Children in malaria endemic area acquire maternal transferred immunity that is thought to be protective in their early months of life. Maternally transferred antibodies, mainly IgG play a critical role. IgG ...
Functional host-genetic loci associated with pediatric HIV-disease progression in Uganda and Botswana.
(2019-10-07)
Background: According to UNAIDS, HIV/AIDS remains a leading cause of morbidity and mortality in children under the age of 15. Distinct conditions of HIV-disease progression have been observed in different populations ...
Renal Lesions At Autopsy Among Adults At Mulago Hospital Over A Five Year Period (2009-2013)
(Makerere University, 2019)
Introduction
Autopsy is one of the techniques that can be utilized to study disease that didn’t present any
suggestive features in life or that was not fully studied in life, and kidney diseases fall in
those diseases ...