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A metabolic biosignature of early response to anti-tuberculosis treatment
(BMC Infectious Diseases, 2014)
Background: The successful treatment of tuberculosis (TB) requires long-term multidrug chemotherapy. Clinical trials to evaluate new drugs and regimens for TB treatment are protracted due to the slow clearance of Mycobacterium ...
Elucidating emergence and transmission of multidrug-resistant tuberculosis in treatment experienced patients by whole genome sequencing
(PLOS One, 2013)
Background: Understanding the emergence and spread of multidrug-resistant tuberculosis (MDR-TB) is crucial for its control. MDR-TB in previously treated patients is generally attributed to the selection of drug resistant ...
Growth patterns and survivability of the different mycobacterium tuberculosis sub lineages predominant in peri urban Kampala
(Makerere University, 2014-05)
Background: Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis (TB) infects over 2 billion people world-wide with the vast majority of deaths from TB in the developing world. Strains of MTB vary in ...
Strain diversity of mycobacterium tuberculosis non-Uganda isolates from patients with pulmonary tuberculosis in Kawempe
(Makerere University, 2013-05)
Background: Tuberculosis is a major public health problem in peri-urban areas of Kampala and Uganda in general. To date there is inconclusive information about strain diversity of Mycobacterium tuberculosis of the non ...