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Assessment of diagnostic capacity of private practitioners in detection of tuberculosis in Juba City, South Sudan
(Makerere University, 2013)
Introduction
Tuberculosis (TB) remains a public health threat globally and is of major health concern in South Sudan. In 2012, TB notification rate for South Sudan was 88/100,000 for new cases and 96/100,000 for all ...
Influence of M. tuberculosis lineage variability within a clinical trial for pulmonary tuberculosis
(PLoS ONE, 2010)
Abstract Recent studies suggest that M. tuberculosis lineage and host genetics interact to impact how active tuberculosis presents clinically. We determined the phylogenetic lineages of M. tuberculosis isolates from ...
Bronchoalveolar lavage enzyme-linked immunospot for diagnosis of smear-negative tuberculosis in HIV infected patients
(Public Library of Science, 2012-06-26)
Background: Peripheral blood interferon-gamma release assays (IGRAs) have sub-optimal sensitivity and specificity for diagnosis of active pulmonary tuberculosis (TB). However, assessment of local immune responses has been ...
Evaluation of capilia TB assay for rapid identification of mycobacterium tuberculosis complex in BACTEC MGIT 960 and BACTEC 9120 blood cultures
(BioMed Central, 2012)
Background: Capilia TB is a simple immunochromatographic assay based on the detection of MPB64 antigen specifically secreted by the Mycobacterium tuberculosis complex (MTC). Capilia TB was evaluated for rapid identification ...
A metabolic biosignature of early response to anti-tuberculosis treatment
(BMC Infectious Diseases, 2014)
Background: The successful treatment of tuberculosis (TB) requires long-term multidrug chemotherapy. Clinical trials to evaluate new drugs and regimens for TB treatment are protracted due to the slow clearance of Mycobacterium ...
Nucleic acid amplification tests for diagnosis of smear-negative TB in a high HIV prevalence setting: a prospective cohort study
(Public Library of Science, 2011-01)
Background: Nucleic acid amplification tests are sensitive for identifying Mycobacterium tuberculosis in populations with positive sputum smears for acid-fast bacilli, but less sensitive in sputum-smear-negative populations. ...
The use of Genotype MTBDRplus assay to assess drug resistance of microbacterium tuberculosis isolates from patients in rural Uganda
(BioMed Central, 2010)
Background: Drug resistance levels and patterns among Mycobacterium tuberculosis isolates from newly diagnosed and previously treated tuberculosis patients in Mbarara Uganda were investigated. Methods: We enrolled, ...
Assessing the role of family support on non adherence to TB treatment by patients in Mulago hospital TB clinic
(Makerere University, 2013-08)
Background: Drug resistance among tuberculosis patients in sub-Saharan Africa is increasing mainly due to poor adherence to TB treatment despite various interventions aimed at improving treatment completion. Family support ...
Time to tuberculosis treatment default and its determinants among adult TB patients in Jinja District, A retrospective cohort study
(Makerere University, 2015-10)
Introduction: Whereas Tuberculosis is both preventable and curable, the disease remains a global health problem causing ill-health among millions of people each year and ranks as the second leading cause of death from an ...
Growth patterns and survivability of the different mycobacterium tuberculosis sub lineages predominant in peri urban Kampala
(Makerere University, 2014-05)
Background: Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis (TB) infects over 2 billion people world-wide with the vast majority of deaths from TB in the developing world. Strains of MTB vary in ...