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Artemisinin Combination Therapies for Treatment of Uncomplicated Malaria in Uganda
(Public Library of Science, 2006-05)
Objectives: To compare the efficacy and safety of artemisinin combination therapies for the treatment of uncomplicated falciparum malaria in Uganda. Design: Randomized single-blind controlled trial. Setting: Tororo, Uganda, ...
Complexity of plasmodium falciparum clinical samples from Uganda during short-term culture.
(University of Chicago Press, 2008-08-22)
We cultured Plasmodium falciparum parasites from 98 Ugandan children with malaria and determined the complexity of infection (COI) on the basis of msp-2 polymorphisms daily for 9 days. The mean COI decreased during culture ...
Genetic polymorphisms in plasmodium falciparum associated with resistance to artemisnin combination therapy: complexity of infection during short-term culture and characterization of in-vitro sensitivity in Kampala Uganda
(2010)
Background Artemisinin-based combination therapy (ACT) is currently advocated in Africa as a means of improving treatment efficacy and slowing the development of drug resistance. However, the selection of resistant parasites, ...