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A metabolic biosignature of early response to anti-tuberculosis treatment
(BMC Infectious Diseases, 2014)
Background: The successful treatment of tuberculosis (TB) requires long-term multidrug chemotherapy. Clinical trials to evaluate new drugs and regimens for TB treatment are protracted due to the slow clearance of Mycobacterium ...
Tuberculosis immune reconstitution inflammatory syndrome in countries with limited resources
(International Union Against Tuberculosis and Lung Disease, 2006)
Mycobacterium tuberculosis infection accounts for probably one third of human immunodeficiency virus (HIV)related immune reconstitution inflammatory syndrome (IRIS) events, particularly in developing countries where HIV ...
Tuberculosis immune reconstitution inflammatory syndrome in countries with limited resources
(International Union Against Tuberculosis and Lung Disease, 2006)
Mycobacterium tuberculosis infection accounts for probably one third of human immunodeficiency virus (HIV)related immune reconstitution inflammatory syndrome (IRIS) events, particularly in developing countries where HIV ...
Growth patterns and survivability of the different mycobacterium tuberculosis sub lineages predominant in peri urban Kampala
(Makerere University, 2014-05)
Background: Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis (TB) infects over 2 billion people world-wide with the vast majority of deaths from TB in the developing world. Strains of MTB vary in ...
Practices of diagnosis and treatment of pulmonary tuberculosis, associated factors, barriers and facilitators among private practitioners in Kampala, Uganda
(Makerere University, 2020-11)
Introduction: Globally, tuberculosis (TB) is a leading cause of morbidity and mortality accounting for an estimated 10.0 million new cases and 1.451million deaths in 2018. Uganda is one of the world’s high TB burden countries ...
Identification of the insertions, deletions and point mutations in rhomboid proteases from selected Mycobacterium species
(Makerere University, 2014-11)
Background: Rhomboids, proteins that are conserved in all life kingdoms, are among the novel genes likely to encode roles in the pathogenesis of mycobacteria. While rhomboids have various specific functions across species, ...
Strain diversity of mycobacterium tuberculosis non-Uganda isolates from patients with pulmonary tuberculosis in Kawempe
(Makerere University, 2013-05)
Background: Tuberculosis is a major public health problem in peri-urban areas of Kampala and Uganda in general. To date there is inconclusive information about strain diversity of Mycobacterium tuberculosis of the non ...
Effect of vitamin d binding protein gene polymorphisms and vitamin d bioavailability on cathelicidin expression in tuberculosis infection and disease
(Makerere University, 2023-01)
Background: The human antimicrobial peptide cathelicidin (LL-37) is involved in host innate immunity by the after activation of Toll-like receptors (TLRs), resulting in direct killing of Mycobacterium tuberculosis (MTB). ...
Patient single nucleotide polymorphisms assiocated with Mycobacterium tuberculosis genotypes in Ugandan population
(Makerere University, 2022-12)
Uganda is one of the 30 World Health Organization-designated countries with a high burden of TB/HIV, with three main dominant genotypes that cause tuberculosis. Recent studies have shown that the M. tuberculosis Uganda ...
Performance evaluation of the Uganda National Algorithm for Diagnosis of tuberculosis in children at Mulago National Referral Hospital-Kampala, Uganda
(Makerere University, 2023)
Background
Diagnosing childhood tuberculosis (TB) is a challenge, this led the Uganda national tuberculosis control program (NTLP) to develop a clinical treatment decision algorithm for children. However, there is limited ...