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High CD56++CD16- natural killer (NK) cells among suboptimal immune responders after four years of suppressive antiretroviral therapy in an African adult HIV treatment cohort
(BMC Immunology, 2014)
Background: Up to 40% of HIV-infected individuals receiving Highly Active Antiretroviral Therapy (HAART) have poor CD4+ T-cell recovery. The role of natural killer (NK) cells in immune recovery during HAART is not well ...
Doctoral training in Uganda: evaluation of mentoring best practices at Makerere University College of Health Sciences
(BMC Medical Education, 2014)
Background: Good mentoring is a key variable for determining success in completing a doctoral program. We identified prevailing mentoring practices among doctoral students and their mentors, identified common challenges ...
Belief in divine healing can be a barrier to antiretroviral therapy adherence in Uganda
(Lippincott Williams & Wilkins., 2007)
Although recent data suggest high levels of adherence to expanding antiretroviral therapy (ART) programmes in resource-limited settings, the culture- specific barriers to adherence are poorly understood. In a prospective ...
HIV-subtype A is associated with poorer neuropsychological performance compared with subtype D in antiretroviral therapy-naive Ugandan children
(Lippincott Williams & Wilkins, 2010)
Background: HIV-subtype D is associated with more rapid disease progression and
higher rates of dementia in Ugandan adults compared with HIV-subtype A. There are no
data comparing neuropsychological function by HIV subtype ...
Prevalence and factors associated with cryptococcal antigenemia among severely immunosuppressed HIV-infected adults in Uganda: a cross-sectional study
(Journal of the International AIDS Society, 2012-03-14)
Background: Cryptococcal infection is a common opportunistic infection among severely immunosuppressed HIV patients and is associated with high mortality. Positive cryptococcal antigenemia is an independent predictor of ...
Strategies to optimize HIV treatment outcomes in resource-limited settings
(Permanyer Publications, 2009)
Although the availability of antiretroviral therapy has increased rapidly to reach over three million people in low- and middle-income countries, coverage remains low as only 31% of people in need were receiving antiretroviral ...
Outcomes of cryptococcal meningitis in Uganda before and after the availability of highly active antiretroviral therapy
(CID, 2008)
Background. Cryptococcal meningitis (CM) is the proximate cause of death in 20%–30% of persons with acquired immunodeficiency syndrome in Africa. Methods. Two prospective, observational cohorts enrolled human immunodeficiency ...
Burden of tuberculosis in Kampala, Uganda
(World Health Organization (WHO), 2008)
Objective: To determine the prevalence and incidence of tuberculosis in one of Uganda’s poor peri-urban areas. Methods: Multi-stage sampling was used to select a sample of households whose members were evaluated for presence ...
Evaluation of Dynabeads and Cytospheres Compared With Flow Cytometry to Enumerate CD41 T Cells in HIV-Infected Ugandans on Antiretroviral Therapy
(Lippincott Williams & Wilkins., 2008-07-01)
Background: Laboratory-based monitoring of antiretroviral therapy is essential but adds a significant cost to HIV care. The World Health Organization 2006 guidelines support the use of CD4 lymphocyte count (CD4) to define ...
Effect of HIV-1 infection on antimalarial treatment outcomes in Uganda: a population-based study.
(University of Chicago Press, 2005-11-18)
Background. Human immunodeficiency virus (HIV) infection may increase the burden of malaria by increasing susceptibility to infection or by decreasing the response to antimalarial treatment. We investigated the seroprevalence ...