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dc.contributor.authorMusoke, David
dc.contributor.authorWaako, Paul John
dc.contributor.authorObua, Celestino
dc.date.accessioned2012-02-16T16:36:42Z
dc.date.available2012-02-16T16:36:42Z
dc.date.issued2008
dc.identifier.citationMusoke, D., Obua, C., Waako, P.J. (2008). Assessment of the drug storage facilities and quality of generic co-formulation tablets (Stavudine, Lamivudine, Nevirapine) at HIV/AIDS treatment centers in Uganda. Research Journal of Medical Science, 2(3)en_US
dc.identifier.issn1815-9346
dc.identifier.urihttp://hdl.handle.net/10570/442
dc.description.abstractThe study investigated the storage facilities and the quality of co-formulation tablets containing stavudine, lamivudine, and nevirapine at four treatment centres in Uganda. A cross-sectional survey of drug storage conditions at four distribution centres randomly selected from the four regions of Uganda was done using a checklist developed from the guidelines for good drug storage practices. Drug batches were sampled at the time of the survey and one month after storage and analysed for quality using appearance, uniformity of weight, dissolution rate and drug content. All treatment centres had satisfactory storage design but lacked facilities for monitoring temperature and humidity. Air-conditioning facilities were also lacking. Batches investigated had average weight deviation of less than 5%; content of active pharmaceutical ingredients lay between 90-110%% and the dissolution rate was greater than 80% in 45 min both on delivery and after one month of storage. The quality of co-formulation tablets containing stavudine, lamivudine and nevirapine was of good quality. However, the storage facilities at the HIV/AIDS treatment centres were inadequate. They need to be provided with facilities to monitor temperature and humidity as the antiretroviral programme expands to cover broader spectrum of drugs.en_US
dc.description.sponsorshipSIDA/SAREC, World Bank, I@Maken_US
dc.language.isoenen_US
dc.publisherMedwell Journalsen_US
dc.subjectHIV/AIDSen_US
dc.subjectAntiretroviral therapyen_US
dc.subjectDrug qualityen_US
dc.subjectCo-formulation tabletsen_US
dc.subjectUgandaen_US
dc.subjectDrug storageen_US
dc.subjectTropical countriesen_US
dc.titleAssessment of the drug storage facilities and quality of generic co-formulation tablets (Stavudine, Lamivudine, Nevirapine) at HIV/AIDS treatment centers in Uganda.en_US
dc.typeJournal article, peer revieweden_US


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