Browsing College of Veterinary Medicine, Animal Resources and BioSecurity (CoVAB) by Subject "Plasmodium falciparum"
Now showing items 1-7 of 7
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Association between malaria preventive treatment regimens in pregnancy and plasmodium falciparum drug resistance mediating polymorphisms in Busia district, Eastern Uganda
(Makerere University, 2020-06)Intermittent preventive treatment in pregnancy (IPTp) with monthly sulfadoxine-pyrimethamine (SP) is recommended for malaria-endemic parts of Africa, but efficacy is compromised by resistance and, in recent trials, ... -
Associations between plasmodium falciparum aminoquinoline resistance genotypes and clinical presentations of malaria in Ugandan children, A case control study of Jinja District and the neighbouring Busoga Sub-Region Districts
(Makerere University, 2023-01)Plasmodium falciparum resistance mutations to aminoquinoline antimalarials are selected by prior drug use and may alter parasite fitness yet their associations with clinical malaria presentations are uncertain. ... -
Congenital plasmodium falciparum infection in a meso-endemic area of Uganda : molecular perspective
(Makerere University, 2022)Malaria remains a major public health concern especially among pregnant women and young children in sub-Saharan Africa. Few studies in Uganda have examined congenital malaria (CM) defined as presence of malaria parasites ... -
Genetic diversity of Plasmodium Falciparum infections at varying altitudes in South-Western Uganda
(Makerere University, 2010-09)Plasmodium falciparum is a highly polymorphic parasite. This sometimes results in a high genetic diversity in the population and high complexity of infections among individuals. Although some studies indicate a relationship ... -
Insilico identification, characterisation of plasmodium falciparum hypothetical proteins and their assessment as molecular targets for malaria vaccine
(Makerere University, 2023-06)This thesis focused on malaria vaccinology and employed reverse vaccinology and molecular techniques to predict potential vaccine candidates against P. falciparum malaria. Reverse vaccinology is fundamentally an in silico ... -
Mopti and savanna molecular forms of the malaria vector anopheles Gambiae S.S populations from Bugiri and Iganga south–eastern Uganda
(Makerere University, 2014-05)Female anopheles mosquitoes transmit malaria in humans and other mammals; Anopheles gambiae sensu stricto which is the primary vector of Plasmodium falciparum has been classified into two molecular forms, Savanna and Mopti. ... -
The role of hyperferritinaemia in pediatric severe malaria pathogenesis and kidney injury
(Makerere University, 2023-01)Ferritin, a highly conserved iron storage protein that sequesters iron from pathogens including Plasmodium falciparum, is part of the acute phase response in malaria pathogenesis. Ferritin levels are elevated in severe ...