Now showing items 1-10 of 11
Detection of mutant P2 adenosine transporter (TbAT1) gene in Trypanosoma brucei gambiense isolates from northwest Uganda using allele-specific polymerase chain reaction
objective To assess the application of allele-specific PCR (AS-PCR) as a fast, cheap and reliable method for detecting mutant TbAT1 associated with melarsoprol relapse in Trypanosoma brucei gambiense isolates from northwest ...
Trypanosoma brucei rhodesiense Transmitted by a Single Tsetse Fly Bite in Vervet Monkeys as a Model of Human African Trypanosomiasis
(Public Library of Science, 2008-05)
We have investigated the pathogenicity of tsetse (Glossina pallidipes)-transmitted cloned strains of Trypanosoma brucei rhodesiense in vervet monkeys. Tsetse flies were confirmed to have mature trypanosome infections by ...
Socio-economic factors influencing control of vector-borne diseases in the pastoralist system of South Western Uganda
(Springer Verlag, 2008)
Research in control of tick-borne diseases and trypanosomosis, and their vectors, namely, ticks and tsetse flies respectively, has been on going for decades. However, very little attention has been paid to the socio-economic ...
Evaluation of Genetic Diversity among Glossina Fuscipes subpopulations from sleeping sickness foci in Uganda using Microsa Tellite DNA markers
(Makerere University, 2008-01)
Vector population genetic structure is rarely analyzed yet it is important in the understanding of the epidemiology of vector borne diseases and their control. In this study, patterns of genetic variation in the tsetse fly ...
A Combined CXCL10, CXCL8 and H-FABP Panel for the Staging of Human African Trypanosomiasis Patients
(Public Library of Science, 2009)
Background: Human African trypanosomiasis (HAT), also known as sleeping sickness, is a parasitic tropical disease. It progresses from the first, haemolymphatic stage to a neurological second stage due to invasion of parasites ...
A burgeoning epidemic of sleeping sickness in Uganda
The epidemic of Trypanosoma brucei rhodesiense sleeping sickness in eastern Uganda, which began in 1998 as a result of movements of the livestock reservoir of the parasite, has continued to spread. An additional 133 000 ...
Genotypic Status of the TbAT1/P2 Adenosine Transporter of Trypanosoma brucei gambiense Isolates from Northwestern Uganda following Melarsoprol Withdrawal
(Public Library of Science, 2009-09)
Background: The development of arsenical and diamidine resistance in Trypanosoma brucei is associated with loss of drug uptake by the P2 purine transporter as a result of alterations in the corresponding T. brucei adenosine ...
Packed cell volume as a measure of procine health and the implication on the control of sleeping sickness in Uganda
(Trakia University, 2003)
Information about pig health in Uganda is greatly lacking and recent studies have indicated a high prevalence of trypanosome infections among pigs kept in tsetse infested and trypanosomosis endemic areas of Southern Uganda. ...
Animal health intervations for human health benefits