dc.contributor.author | Wong, M. H. | |
dc.contributor.author | Robertson, K. | |
dc.contributor.author | Nakasujja, N | |
dc.contributor.author | Skolasky, R. | |
dc.contributor.author | Musisi, S. | |
dc.contributor.author | Katabira, E. | |
dc.contributor.author | McArthur, J. C. | |
dc.contributor.author | Ronald, A. | |
dc.contributor.author | Sacktor, N. | |
dc.date.accessioned | 2012-12-17T12:32:07Z | |
dc.date.available | 2012-12-17T12:32:07Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | Wong, M.H., Robertson, K., Nakasujja, N., Skolasky, R., Musisi, S., Katabira, E., McArthur, J.C., Ronald, A., Sacktor, N. (2007). Frequency of and risk factors for HIV dementia in an HIV clinic in sub-Saharan Africa. Neurology Journal, 68(5) | en_US |
dc.identifier.issn | 1526-632X | |
dc.identifier.uri | http://www.neurology.org/cgi/content/full/68/5/350 | |
dc.identifier.uri | http://hdl.handle.net/10570/927 | |
dc.description.abstract | Objective: To measure the frequency and associated risk factors of HIV dementia in an HIV clinic in Kampala, Uganda. Methods: We systematically sampled 78 HIV-seropositive (HIV ) patients from an ambulatory HIV clinic.
Participants underwent detailed sociodemographic, medical history, functional, neurologic, and neuropsychological evaluations.
One hundred HIV-negative patients were recruited to provide normative data for the neuropsychological tests. A logistic regression model was constructed to determine risk factors associated with the diagnosis of HIV dementia. Results:
Thirty-one percent (24 of 78) of the HIV patients had HIV dementia. Advanced age and low CD4 T-lymphocyte count (CD4 count) were the only variables identified as significant risk factors in the logistic regression model. Each additional
10 years of age conferred a greater than twofold risk of HIV dementia (OR 2.06, 95% CI: 1.05 to 4.07; p 0.05). Reduced levels of CD4 count (100 cells/ L decrement) was associated with a 60% increase in the odds of having HIV dementia (OR 1.6, 95% CI: 1.04 to 2.33; p 0.05). Conclusion: HIV dementia is common in HIV-seropositive Ugandan individuals attending an AIDS clinic. It is more frequently associated with patients of advanced age and decreased CD4 count. | en_US |
dc.language.iso | en | en_US |
dc.publisher | American Academy of Neurology | en_US |
dc.subject | HIV | en_US |
dc.subject | Risk factors | en_US |
dc.subject | Sub-Saharan Africa | en_US |
dc.subject | CD4 Cell Count | en_US |
dc.subject | Neuropsychology | en_US |
dc.subject | CD4 T-lymphocyte count | en_US |
dc.subject | HIV-seropositive | en_US |
dc.title | Frequency of and risk factors for HIV dementia in an HIV clinic in sub-Saharan Africa | en_US |
dc.type | Journal article, peer reviewed | en_US |