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dc.contributor.authorWong, M. H.
dc.contributor.authorRobertson, K.
dc.contributor.authorNakasujja, N
dc.contributor.authorSkolasky, R.
dc.contributor.authorMusisi, S.
dc.contributor.authorKatabira, E.
dc.contributor.authorMcArthur, J. C.
dc.contributor.authorRonald, A.
dc.contributor.authorSacktor, N.
dc.date.accessioned2012-12-17T12:32:07Z
dc.date.available2012-12-17T12:32:07Z
dc.date.issued2007
dc.identifier.citationWong, M.H., Robertson, K., Nakasujja, N., Skolasky, R., Musisi, S., Katabira, E., McArthur, J.C., Ronald, A., Sacktor, N. (2007). Frequency of and risk factors for HIV dementia in an HIV clinic in sub-Saharan Africa. Neurology Journal, 68(5)en_US
dc.identifier.issn1526-632X
dc.identifier.urihttp://www.neurology.org/cgi/content/full/68/5/350
dc.identifier.urihttp://hdl.handle.net/10570/927
dc.description.abstractObjective: To measure the frequency and associated risk factors of HIV dementia in an HIV clinic in Kampala, Uganda. Methods: We systematically sampled 78 HIV-seropositive (HIV ) patients from an ambulatory HIV clinic. Participants underwent detailed sociodemographic, medical history, functional, neurologic, and neuropsychological evaluations. One hundred HIV-negative patients were recruited to provide normative data for the neuropsychological tests. A logistic regression model was constructed to determine risk factors associated with the diagnosis of HIV dementia. Results: Thirty-one percent (24 of 78) of the HIV patients had HIV dementia. Advanced age and low CD4 T-lymphocyte count (CD4 count) were the only variables identified as significant risk factors in the logistic regression model. Each additional 10 years of age conferred a greater than twofold risk of HIV dementia (OR 2.06, 95% CI: 1.05 to 4.07; p 0.05). Reduced levels of CD4 count (100 cells/ L decrement) was associated with a 60% increase in the odds of having HIV dementia (OR 1.6, 95% CI: 1.04 to 2.33; p 0.05). Conclusion: HIV dementia is common in HIV-seropositive Ugandan individuals attending an AIDS clinic. It is more frequently associated with patients of advanced age and decreased CD4 count.en_US
dc.language.isoenen_US
dc.publisherAmerican Academy of Neurologyen_US
dc.subjectHIVen_US
dc.subjectRisk factorsen_US
dc.subjectSub-Saharan Africaen_US
dc.subjectCD4 Cell Counten_US
dc.subjectNeuropsychologyen_US
dc.subjectCD4 T-lymphocyte counten_US
dc.subjectHIV-seropositiveen_US
dc.titleFrequency of and risk factors for HIV dementia in an HIV clinic in sub-Saharan Africaen_US
dc.typeJournal article, peer revieweden_US


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