| dc.description.abstract | Kidney disease is a global health concern, with a prevalence of 8-16%. In Sub-Saharan Africa (SSA), 13.9% of HIV-infected youths are affected, with Uganda having an even higher prevalence of 21.5%. This study aimed to address the knowledge gap on kidney disease among HIV-infected individuals in Uganda by determining its prevalence and associated factors among patients attending the Baylor HIV clinic in Kampala. A cross-sectional study of 889 HIV patients at Baylor HIV Clinic (Dec 2019) were investigated for kidney disease (eGFR <90 ml/min/1.73m²). Secondary data abstraction was done to obtain data on the socio-demographic, behavioral, and medical history characteristics of the patients. The data was analyzed in STATA version 14 using logistic regression at bivariate and multivariate level to determine the factors associated with Kidney disease. In this study, 899 participants were initially enrolled, and 773 had complete information on key study variables and were included in the analysis. The prevalence of kidney disease was found to be low, at 7.2% (56/773). Among these 773 participants, 60.2% (465/773) were below 18 years, 52% (402/773) were females, 69.5% (537/773) did not consume alcohol, 2.1% (16/773) smoked, 83.2% (643/773) had viral loads <1000, 51.6% (399/733) had CD4 counts <1000. The most common current ART regimen was NNRTI-based 87.97% (680/773), and the most common previous ART regimen was Protease-based 67.66% (523/773). Being overweight (AOR: 5.83, 95% CI: 1.57–21.68), having secondary education (AOR: 5.08, 95% CI: 1.83–14.13), age ≥18 years (AOR 5.40, 95% CI: 2.62–11.12), female gender [AOR: 7.06 (95% CI: 2.49–19.98), p < 0.001]. and being informally employed [AOR: 3.18 (95% CI: 1.22–8.29), p = 0.018] were associated with higher odds of kidney disease whereas having a protease inhibitor based previous ART regimen [AOR 0.46,95% CI(0.24-0.90) was associated with reduced odds of kidney disease. The study revealed a relatively low kidney disease prevalence among PLWH at Baylor COE clinic, Uganda. This is attributed to the clinic's specialized care, but highlights the need for continued vigilance and monitoring, particularly among those with identified factors such as older age. There is a need for targeted interventions to reducing the risk of kidney disease, including enhanced gender-specific screening and preventive measures, more frequent kidney function assessments for older individuals, close monitoring for nephrotoxicity among those on NNRTI-based ART regimens, and further investigation into the lower risk observed among unemployed individuals to guide public health interventions. | en_US |
