Browsing School of Health Sciences (Health-Sciences) Collections by Author "Rosenthal, Philip J."
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Artemether-Lumefantrine versus Dihydroartemisinin-Piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda
Yeka, Adoke; Kamya, Moses R.; Dorsey, Grant; Talisuna, Ambrose; Lugemwa, Myers; Rwakimari, John Bosco; Staedke, Sarah G.; Rosenthal, Philip J.; Wabwire-Mangen, Fred; Bukirwa, Hasifa (Public Library of Science, 2008-06)Background: Uganda recently adopted artemether-lumefantrine (AL) as the recommended first-line treatment for uncomplicated malaria. However, AL has several limitations, including a twice-daily dosing regimen, recommendation ... -
Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial.
Kamya, Moses.R; Yeka, Adoke; Bukirwa, Hasifa; Lugemwa, Myers; Rwakimari, John B.; Staedke, Sarah G.; Talisuna, Ambrose O.; Greenhouse, Bryan; Nosten, Francois; Rosenthal, Philip J.; Wabwire-Mangen, Fred; Dorsey, Grant (2007-05-18)Objectives: To compare the efficacy and safety of artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP) for treating uncomplicated falciparum malaria in Uganda. Design: Randomized single-blinded clinical ... -
Artemisinin Combination Therapies for Treatment of Uncomplicated Malaria in Uganda
Bukirwa, Hasifa; Talisuna, Ambrose; Yeka, Adoke; Kamya, Moses R; Talisuna, Ambrose O.; Banek, Kristin; Bakyaita, Nathan; Rwakimari, John Bosco; Rosenthal, Philip J.; Wabwire-Mangen, Fred; Dorsey, Grant; Staedke, Sarah G. (Public Library of Science, 2006-05)Objectives: To compare the efficacy and safety of artemisinin combination therapies for the treatment of uncomplicated falciparum malaria in Uganda. Design: Randomized single-blind controlled trial. Setting: Tororo, Uganda, ... -
Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda
Banek, Kristin; Yeka, Adoke; Bakyaita, Nathan; Staedke, Sarah G.; Talisuna, Ambrose; Kironde, Fred; Kamya, Moses.R; Nsobya, Samuel L.; Kilian, Albert; Slater, Madeline; Dorsey, Grant; Wabwire-Mangen, Fred; Rosenthal, Philip J.; Reingold, Arthur (Public Library of Science, 2005-07)Background Drug resistance in Plasmodium falciparum poses a major threat to malaria control. Combination antimalarial therapy including artemisinins has been advocated recently to improve efficacy and limit the spread of ... -
Complexity of plasmodium falciparum infections and antimalarial drug efficacy at 7 sites in Uganda.
Sulggi, Less A.; Nsobya, Samuel L.; Yeka, Adoke; Dokomajilar, Christian; Rosenthal, Philip J.; Talisuna, Ambrose; Dorsey, Grant (University of Chicago Press, 2006-03-13)Malaria infections in Africa frequently include multiple parasite strains.We examined the relationship between the number of infecting Plasmodium falciparum strains and the responses to 3 different combination therapies ... -
Effect of HIV-1 infection on antimalarial treatment outcomes in Uganda: a population-based study.
Kamya, Moses R.; Gasasira, Anne F.; Yeka, Adoke; Bakyaita, Nathan; Nsobya, Samuel L.; Damon, Francis; Rosenthal, Philip J.; Dorsey, Grant; Havlir, Diane (University of Chicago Press, 2005-11-18)Background. Human immunodeficiency virus (HIV) infection may increase the burden of malaria by increasing susceptibility to infection or by decreasing the response to antimalarial treatment. We investigated the seroprevalence ... -
Selection of parasites with diminished drug susceptibility by amodiaquine-containing antimalarial regimens in Uganda.
Nawaz, Fatima; Nsobya, Samuel L.; Kiggundu, Moses; Joloba, Moses; Rosenthal, Philip J. (Oxford University Press, 2009-11-04)Background. Amodiaquine (AQ) is paired with artesunate (AS) or sulfadoxine-pyrimethamine (SP) in recommended antimalarial regimens. It is unclear how readily AQ resistance will be selected with combination chemotherapy. ... -
Selection of plasmodium falciparum pfmdr1 Alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic
Nsobya, Samuel L.; Dokomajilar, Christian; Greenhouse, Bryan; Rosenthal, Philip J.; Dorsey, Grant (American Society for Microbiology, 2006-03-08)Polymorphisms in the Plasmodium falciparum pfmdr1 gene were assayed in pretreatment samples and in samples from patients reinfected following therapy with artemether-lumefantrine. The pfmdr1 alleles 86N,184F, and 1246D ... -
Sulfadoxine-pyrimethamine plus chloroquine or amodiaquine for uncomplicated falciparum malaria: a randomized, multisite trial to guide national policy in Uganda
Bakyaita, Nathan; Dorsey, Grant; Adoke, Yeka; Banek, Kristin; Staedke, Sarah G.; Kamya, Moses R.; Talisuna, Ambrose; Kironde, Fred; Nsobya, Sam; Kilian, Albert; Reingold, Arthur; Rosenthal, Philip J.; Wabwire-Mangen, Fred (2005)The use of combinations of inexpensive drugs for the treatment of malaria in Africa has been proposed as an interim policy while awaiting the widespread availability of more effective regimens. We compared sulfadoxinepyrimethamine ...