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dc.contributor.authorEller, Leigh A.
dc.contributor.authorEller, Michael A.
dc.contributor.authorOuma, Benson J.
dc.contributor.authorKataaha, Peter
dc.contributor.authorBagaya, Bernard S.
dc.contributor.authorOlemukan, Robert L.
dc.contributor.authorErima, Simon
dc.contributor.authorKawala, Lillian
dc.contributor.authorde Souza, Mark S.
dc.contributor.authorKibuuka, Hannah
dc.contributor.authorWabwire-Mangen, Fred
dc.contributor.authorPeel, Sheila A.
dc.contributor.authorO'Connell, Robert J.
dc.contributor.authorRobb, Merlin L.
dc.contributor.authorMichael, Nelson L.
dc.date.accessioned2013-07-05T08:11:18Z
dc.date.available2013-07-05T08:11:18Z
dc.date.issued2007-10
dc.identifier.issn0095-1137
dc.identifier.urihttp://hdl.handle.net/10570/1837
dc.description.abstractThe use of rapid tests for human immunodeficiency virus (HIV) has become standard in HIV testing algorithms employed in resource-limited settings. We report an extensive HIV rapid test validation study conducted among Ugandan blood bank donors at low risk for HIV infection. The operational characteristics of four readily available commercial HIV rapid test kits were first determined with 940 donor samples and were used to select a serial testing algorithm. Uni-Gold Recombigen HIV was used as the screening test, followed by HIV-1/2 STAT-PAK for reactive samples. OraQuick HIV-1 testing was performed if the first two test results were discordant. This algorithm was then tested with 5,252 blood donor samples, and the results were compared to those of enzyme immunoassays (EIAs) and Western blotting. The unaddjusted algorithm sensitivity and specificity were 98.6 and 99.9%, respectively. The adjusted sensitivity and specificity were 100 and 99.96%, respectively. This HIV testing algorithm is a suitable alternative to EIAs and Western blotting for Ugandan blood donors.en_US
dc.language.isoenen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.subjectHIVen_US
dc.subjectBlood Banksen_US
dc.subjectHuman Immunodeficiency Virusen_US
dc.subjectUgandaen_US
dc.titleLarge-scale human immunodefficiecy virus rapid test evaluation in a low-prevalence Ugandan blood bank populationen_US
dc.typeJournal article, peer revieweden_US


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