Browsing Infectious Diseases Institute (IDI) by Author "Janoff, Edward N."
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Cellular immune activation in cerebrospinal fluid from Ugandans with cryptococcal meningitis and immune reconstitution inflammatory syndrome
Meya, David B.; Okurut, Samuel; Zziwa, Godfrey; Rolfes, Melissa A.; Kelsey, Melander; Cose, Steve; Joloba, Moses; Naluyima, Prossy; Palmer, Brent E.; Kambugu, Andrew; Mayanja-Kizza, Harriet; Bohjanen, Paul R.; Eller, Michael A.; Wahl, Sharon M.; Boulware, David R.; Manabe, Yuka C.; Janoff, Edward N. (Oxford University Press, 2015)Background. Human immunodeficiency virus (HIV)-associated cryptococcal meningitis (CM) is characterized by high fungal burden and limited leukocyte trafficking to cerebrospinal fluid (CSF). The immunopathogenesis of CMimmune ... -
Clinical features and serum biomarkers in HIV immune reconstitution inflammatory syndrome after cryptococcal meningitis: A prospective cohort study
Boulware, David R.; Meya, David B.; Bergemann, Tracy L.; Wiesner, Darin L.; Rhein, Joshua; Musubire, Paul; Lee, Sarah J.; Kambugu, Andrew; Janoff, Edward N.; Bohjanen, Paul R. (PLoS Medicine, 2010)Background: Although antiretroviral therapy (ART) improves survival in persons with cryptococcal meningitis (CM) and AIDS, ART frequently elicits HIV immune reconstitution inflammatory syndrome (IRIS), an exaggerated and ... -
Outcomes of cryptococcal meningitis in Uganda before and after the availability of highly active antiretroviral therapy
Kambugu, Andrew; Meya, David B.; Rhein, Joshua; O’Brien, Meagan; Janoff, Edward N.; Ronald, Allan R.; Kamya, Moses R.; Mayanja-Kizza, Harriet; Sande, Merle A.; Bohjanen, Paul R.; Boulware, David R. (CID, 2008)Background. Cryptococcal meningitis (CM) is the proximate cause of death in 20%–30% of persons with acquired immunodeficiency syndrome in Africa. Methods. Two prospective, observational cohorts enrolled human immunodeficiency ... -
Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings
Meintjes, Graeme; Lawn, Stephen D.; Scano, Fabio; Maartens, Gary; French, Martyn A.; Worodria, William; Elliott, Julian H.; Murdoch, David; Wilkinson, Robert J.; Seyler, Catherine; John, Laurence; Lynen, Lut; Janoff, Edward N.; Gilks, Charles; Colebunders, Robert; van der Loeff, Maarten Schim (Elsevier, 2008-08)The immune reconstitution inflammatory syndrome (IRIS) has emerged as an important early complication of antiretroviral therapy (ART) in resource-limited settings, especially in patients with tuberculosis. However, there ... -
Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings
Meintjes, Graeme; Lawn, Stephen D.; Scano, Fabio; Maartens, Gary; French, Martyn A.; Worodria, William; Elliott, Julian H.; Murdoch, David; Wilkinson, Robert J.; Seyler, Catherine; John, Laurence; van der Loeff, Maarten Schim; Reiss, Peter; Lynen, Lut; Janoff, Edward N.; Gilks, Charles; Colebunders, Robert (Elsevier, 2008-08)The immune reconstitution inflammatory syndrome (IRIS) has emerged as an important early complication of antiretroviral therapy (ART) in resource-limited settings, especially in patients with tuberculosis. However, there ...