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A metabolic biosignature of early response to anti-tuberculosis treatment
(BMC Infectious Diseases, 2014)
Background: The successful treatment of tuberculosis (TB) requires long-term multidrug chemotherapy. Clinical trials to evaluate new drugs and regimens for TB treatment are protracted due to the slow clearance of Mycobacterium ...
Determinants of health related quality of life in smear positive and smear negative adult tuberculosis patients in Kampala, Uganda
(Makerere University, 2014)
Introduction/background: Smear negative Tuberculosis has been on the rise since the HIV
epidemic and is associated with poor clinical outcomes. There is limited information regarding
health related quality of life(HRQoL) ...
Factors associated with healthcare workers’ adherence to national guidelines for MDR TB surveillance in Uganda: A case study of the West Nile region
(Makerere University, 2014)
Background:
A previous history of tuberculosis (TB) treatment has been identified as a risk factor for multidrug resistant TB. Therefore these patients are a high priority group for whom culture and drug-susceptibility ...
Evaluation of the GenoType MTBDRplus v2 Line Probe Assay for Rapid Diagnosis of Multidrug Resistant Tuberculosis in Uganda
(Makerere University, 2014)
Introduction: Multidrug-resistant tuberculosis (MDR-TB) poses a major challenge to TB control due to its complex diagnostic and treatment challenges. Globally, 3.7% of new cases and 20% of previously treated cases are ...
Growth patterns and survivability of the different mycobacterium tuberculosis sub lineages predominant in peri urban Kampala
(Makerere University, 2014-05)
Background: Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis (TB) infects over 2 billion people world-wide with the vast majority of deaths from TB in the developing world. Strains of MTB vary in ...
Identification of the insertions, deletions and point mutations in rhomboid proteases from selected Mycobacterium species
(Makerere University, 2014-11)
Background: Rhomboids, proteins that are conserved in all life kingdoms, are among the novel genes likely to encode roles in the pathogenesis of mycobacteria. While rhomboids have various specific functions across species, ...