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Sub-optimal CD4 reconstitution despite viral suppression in an urban cohort on Antiretroviral Therapy (ART) in sub-Saharan Africa: Frequency and clinical significance

Nakanjako, Damalie; Kiragga, Agnes; Ibrahim, Fowzia; Castelnuovo, Barbara; Kamya, Moses R.; Easterbrook, Philippa J. (BioMed Central, 2008-10)

Background: A proportion of individuals who start antiretroviral therapy (ART) fail to achieve adequate CD4 cell reconstitution despite sustained viral suppression. We determined the frequency and clinical significance of ...

Cost Effectiveness of a Pharmacy-Only Refill Program in a Large Urban HIV/AIDS Clinic in Uganda

Babigumira, Joseph B; Castelnuovo, Barbara; Stergachis, Andy; Kiragga, Agnes; Shaefer, Petra; Lamorde, Mohammed; Kambugu, Andrew; Muwanga, Alice; Garrison, Louis P. (Public Library of Science, 2011-03-28)

Background: HIV/AIDS clinics in Uganda and other low-income countries face increasing numbers of patients and workforce shortages. We performed a cost-effectiveness analysis comparing a Pharmacy-only Refill Program (PRP), ...

Cause-Specific Mortality and the Contribution of Immune Reconstitution Inflammatory Syndrome in the First 3 Years after Antiretroviral Therapy Initiation in an Urban African Cohort

Castelnuovo, Barbara; Manabe, Yukari C; Kiragga, Agnes; Kamya, Moses; Easterbrook, Philippa; Kambugu, Andrew (Infectious Diseases Society of America, 2009)

Background. Although many studies have reported high early mortality among patients enrolled in antiretroviral therapy (ART) programs in sub-Saharan Africa—particularly among those individuals with advanced immunodeficiency— ...

Efficacy and safety of dolutegravir or darunavir in combination with lamivudine plus either zidovudine or tenofovir for second-line treatment of HIV infection (NADIA): week 96 results from a prospective, multicentre, open-label, factorial, randomised, non-inferiority trial

Paton, Nichilas I.; Musaazi, Joseph; Kityo, Cissy; Walimbwa, Stephen; Hoppe, Anne; Balyegisawa, Apolo; Asienzo, Jesca; Kaimal, Arvind; Mirembe, Grace; Lugemwa, Abbas; Ategeka, Gilbert; Borok, Margaret; Mugerwa, Henry; Siika, Abraham; Odongpiny, Eva Laker A.; Castelnuovo, Barbara; Kiragga, Agnes; Kambugu, Andrew (Elsevier, 2022-04-20)

Background WHO guidelines recommend dolutegravir plus two nucleoside reverse transcriptase inhibitors (NRTIs) for second-line HIV therapy, with NRTI switching from first-line tenofovir to zidovudine. We aimed to ...