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Prevalence, patterns and factors associated with ocular manifestations of type 1 diabetes mellitus among children and adolescents attending Mulago National Referral Hospital
(Makerere University, 2021-12)
Background; Diabetes mellitus is a growing public health challenge in sub-Saharan Africa, Uganda inclusive, with an annual incidence of 6% in the Sub-Saharan Africa region, 3% in many countries and 77% in the European ...
The age-specific incidence of hospitalized paediatric malaria in Uganda
(BMC, 2020)
Background: Understanding the relationship between malaria infection risk and disease outcomes represents a fundamental component of morbidity and mortality burden estimations. Contemporary data on severe malaria risks ...
Malaria diagnosed in an urban setting strongly associated with recent overnight travel: A case–control study from Kampala, Uganda
(2020)
Malaria is frequently diagnosed in urban Kampala, despite low transmission intensity. To evaluate the association between recent travel out of Kampala and malaria, we conducted a matched case–control study. Cases were ...
Methods to estimate baseline creatinine and define acute kidney injury in lean Ugandan children with severe malaria: A prospective cohort study
(BMC, 2020)
Background: Acute kidney injury (AKI) is increasingly recognized as a consequential clinical complication in children with severe malaria. However, approaches to estimate baseline creatinine (bSCr) are not standardized in ...
Retention in HIV care among adolescents living with HIV at Naguru Hospital: Effect of COVID-19 restrictive measures and other associated factors
(Makerere University, 2022-12)
Introduction; In 2020, there were about 1.75 million adolescents living with HIV (ALWHIV) around the world. Approximately 1.5 million HIV-infected adolescents were from Sub-Saharan Africa, and by the end of 2019, about 7% ...
Neutrophil gelatinase-associated lipocalin is elevated in children with acute kidney injury and sickle cell anemia, and predicts mortality
(Elsevier, 2022)
Urine neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker of acute kidney injury that has been adapted to a urine dipstick test. However, there is limited data on its use in low and-middle-income countries ...
Low-level viraemia: An emerging concern among people living with HIV in Uganda and across sub-Saharan Africa
(AOSIS, 2022)
Attaining viral load (VL) suppression for over 95% of the people living with HIV on antiretroviral therapy is a fundamental step in enabling Uganda and other sub-Saharan African countries to achieve global Sustainable ...
Outcomes and predictors of survival among children with hodgkin lymphoma at Uganda Cancer Institute
(Makerere University, 2022-11)
Background: Hodgkin Lymphoma (HL) is one of the most curable childhood malignancies. HL represents 6% of all childhood cancers and has an incidence rate of 12 cases/million/year in the 0–14-year age group worldwide It has ...
Exploring the global genetic diversity of P. falciparum Pf113 malaria vaccine candidate gene
(Makerere University, 2022)
The malaria disease burden is still of great concern especially in sub-Saharan Africa among children below the age of 5 years. Evolution of the P. falciparum parasite in response to intervention measures as well as the ...
Pharmacokinetic/pharmacodynamic Modeling to optimize efavirenz dosing in HIV/AIDs infected children from Sub-Saharan Africa.
(Makerere University, 2022-12)
Aim:Using a model‐based approach, the efavirenz steady‐state pharmacokinetics in Sub-Saharan African children is characterized, quantifying demographic and genotypic effects on the drug's disposition. Simulations are also ...