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Prevalence and factors associated with pulmonary tuberculosis among children 5-15 years attending six health centres in Kampala city

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dc.contributor.author Kizito, Samuel,
dc.date.accessioned 2018-01-05T23:22:23Z
dc.date.available 2018-01-05T23:22:23Z
dc.date.issued 2015
dc.identifier.uri http://hdl.handle.net/10570/5833
dc.description Prevalence and factors associated with pulmonary tuberculosis among children 5-15 years attending Six Health Centres in Kampala city en_US
dc.description.abstract Introduction: Uganda is 19th of 22 high TB burden countries yet childhood TB is neglected; lagging TB contact tracing, poor recording and reporting with notification mainly based on smear results. With the high burden of adult TB and HIV in Uganda, the burden of TB in children is expected to be high but there is paucity of good quality data and uncertainty in actual prevalence of childhood TB in Uganda. Objective: To determine the prevalence and factors associated with pulmonary Tuberculosis among children attending primary health care facilities in Kampala. Methods: A cross-sectional study among 255 children 5 to 15 years, attending 6 primary health care facilities between February and April 2015. Data was collected using a questionnaire including the following information; socio-demographics, clinical history and examination; chest x – ray results, HIV serology, smear positive TB based on sputum using smear ZN or FM staining techniques; and Gene xpert analysis of two samples. Smear negative TB was diagnosed clinically based on the algorithm from a Desk Guide under evaluation. HIV was tested as per the national HIV rapid testing algorithm. The data was entered in Epidata software, and exported to stata for analysis. Multivariable logistic regression was used to identify the associated factors, whilst the WHO. Anthro-plus was used for analysis of nutritional status. Results The overall prevalence of PTB was high at 13.7 % (95% CI: 2.6 – 24.8). This prevalence varied among the HIV positive (41.7%), malnourished children (21.7%) and children with a history of contact (89.3%). Factors that influenced PTB included: tobacco smoker at home (OR = 1.6, 95 % CI: 1.07 – 6.86), stunting (OR = 2.2, 95 % CI: 1.01 – 4.15). Only 1/19 (5.3%) of the clinically diagnosed PTB children and 13/16 (81.3%) of the microbiologically confirmed PTB children were initiated on treatment within a month of diagnosis. Conclusion There is a high prevalence of pulmonary tuberculosis among children in Kampala more-so in HIV positive, malnourished and those with history of TB contact. There is need to lay strategies to lower malnutrition, fight HIV among children, and intensify contact tracing so as to boost the fight against childhood tuberculosis en_US
dc.description.sponsorship University of California San Francisco-University of California Berkeley, Makerere University (UCSF-UCB-MU) collaboration through AIDS/HIV International Training Research Program (PART) en_US
dc.language.iso en en_US
dc.subject Uganda is 19th of 22 high en_US
dc.subject TB burden en_US
dc.subject childhood TB en_US
dc.subject TB and HIV en_US
dc.subject burden of TB in children en_US
dc.title Prevalence and factors associated with pulmonary tuberculosis among children 5-15 years attending six health centres in Kampala city en_US
dc.type Thesis/Dissertation (Masters) en_US


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