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dc.contributor.authorRajasingham, Radha
dc.contributor.authorMeya, David B.
dc.contributor.authorBoulware, David R.
dc.date.accessioned2012-12-03T13:34:08Z
dc.date.available2012-12-03T13:34:08Z
dc.date.issued2012-04-15
dc.identifier.citationRajasingham, R., Meya, D. B. & Boulware, D. R. (2012). Integrating cryptococcal antigen screening andpPre-emptive treatment into routine HIV care. Journal of Acquired Immune Deficiency Syndromes, 59(5):en_US
dc.identifier.issn1525-4135
dc.identifier.urihttp://www.jaids.com
dc.identifier.urihttp://hdl.handle.net/10570/905
dc.description.abstractCryptococcal meningitis is a leading cause of death in AIDS patients in sub-Saharan Africa. Cryptococcal antigen (CRAG) can be detected weeks before onset of symptoms, and those who are asymptomatic but CRAG positive have a high risk of subsequent cryptococcal meningitis and mortality. A new CRAG point of care immunochromatographic test is available that is remarkably easy to administer without laboratory infrastructure or expertise and has excellent sensitivity and specificity. We review the benefits of targeted CRAG screening, developments in CRAG diagnostics, and evidence regarding treatment options that can be implemented into routine HIV care in areas of high cryptococcal burden. Based on published CRAG+ prevalence rates of 2%–12%, the cost to save one life is between $20 to $140 in sub-Saharan Africa. We provide recommendations for implementation, pre-emptive treatment, and identify the gaps in our current knowledge.en_US
dc.description.sponsorshipSupported by NIH NIAID for DRB from K23AI073192-03 and for DBM, RR from U01AI089244-02.en_US
dc.language.isoenen_US
dc.publisherLippincott, Williams & Wilkinsen_US
dc.subjectHIVen_US
dc.subjectCryptococcosisen_US
dc.subjectCryptococcal meningitis/DIen_US
dc.subjectCost effectivenessen_US
dc.subjectPoint-of-care systemsen_US
dc.titleIntegrating cryptococcal antigen screening andpPre-emptive treatment into routine HIV careen_US
dc.typeJournal article, peer revieweden_US


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