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dc.contributor.authorSendagire, Ibrahim
dc.contributor.authorKambugu, Andrew
dc.contributor.authorKonde-Lule, Joseph
dc.contributor.authorCobelens, Frank
dc.contributor.authorSchim Van der Loeff, Maarten
dc.date.accessioned2013-01-03T11:50:31Z
dc.date.available2013-01-03T11:50:31Z
dc.date.issued2012-05-02
dc.identifier.citationSendagire, I., Schim Van der Loeff, M., Konde-Lule, J., Cobelens, F. (2012). Urban movement and alcohol intake strongly predict defaulting from tuberculosis treatment: an operational study. PLoS One, 7(5)en_US
dc.identifier.issn1932-6203
dc.identifier.uridoi:10.1371/journal.pone.0035908
dc.identifier.urihttp://hdl.handle.net/10570/945
dc.description.abstractBackground:High levels of defaulting from treatment challenge tuberculosis control in many African cities. We assessed defaulting from tuberculosis treatment in an African urban setting. Methods: An observational study among adult patients with smear-positive pulmonary tuberculosis receiving treatment at urban primary care clinics in Kampala, Uganda. Defaulting was defined as having missed two consecutive monthly clinic visits while not being reported to have died or continued treatment elsewhere. Defaulting patients were actively followedup and interviewed. We assessed proportions of patients abandoning treatment with and without the information obtained through active follow-up and we examined associated factors through multivariable logistic regression. Results: Between April 2007 and April 2008, 270 adults aged $15 years were included; 54 patients (20%) were recorded as treatment defaulters. On active follow-up vital status was established of 28/54 (52%) patients. Of these, 19 (68%) had completely stopped treatment, one (4%) had died and eight (29%) had continued treatment elsewhere. Extrapolating this to all defaulters meant that 14% rather than 20% of all patients had truly abandoned treatment. Daily consumption of alcohol, recorded at the start of treatment, predicted defaulting (adjusted odds ratio [ORadj] 4.4, 95%CI 1.8–13.5), as did change of residence during treatment (ORadj 8.7, 95%CI 1.8–41.5); 32% of patients abandoning treatment had changed residence. Conclusions: A high proportion of tuberculosis patients in primary care clinics in Kampala abandon treatment. Assessing change of residence during scheduled clinic appointments may serve as an early warning signal that the patient may default and needs adherence counseling.en_US
dc.description.sponsorshipNetherlands African Partnership for Clinical Trials and Capacity Building Program (NACCAP: http://www.nwo.nl/nwohome.nsf/pages/NWOP_5VWBMM_eng)en_US
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.subjectTuberculosisen_US
dc.subjectAlcoholismen_US
dc.subjectTuberculosis treatmenten_US
dc.subjectUgandaen_US
dc.subjectPulmonary tuberculosisen_US
dc.titleUrban movement and alcohol intake strongly predict defaulting from tuberculosis treatment: an operational studyen_US
dc.typeJournal article, peer revieweden_US


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