Browsing School of Bio-Medical Sciences (Bio-Medical) Collections by Type
Now showing items 1-20 of 28
-
Activation of the gab Operon in an RpoS-Dependent Manner by Mutations That Truncate the Inner Core of Lipopolysaccharide in Escherichia coli
(American Society for Microbiology, 2004-12)The gab operon (gabDTPC) in Escherichia coli functions in the conversion of -aminobutyrate to succinate. One component of gab operon regulation involves the RpoS sigma factor, which mediates activation at high cell density. ... -
Blood and body fluid exposures among surgeons in Mulago hospital
(COSECSA/ASEA, 2011-11)Background: It is now recognized that health workers are at risk of acquiring infection with hepatitis B virus (HBV), hepatitis C virus (HCV), HIV and other blood borne pathogens through contact with infected blood and ... -
Community-acquired pneumonia in Ugandan adults: short-term parenteral ampicillin therapy for bacterial pneumonia
(The American Society of Tropical Medicine and Hygiene, 2001)A hospital-based prospective study of 99 patients with community-acquired pneumonia (CAP) was carried out in Kampala, Uganda. We evaluated microbiological etiologies, clinical features and effectiveness of short term ... -
Comparison of methods in the recovery of nucleic acids from archival formalin-fixed paraffin-embedded autopsy tissues
(Elsevier, 2010)Archival formalin-fixed paraffin-embedded (FFPE) human tissue collections are typically in poor states of storage across the developing world. With advances in biomolecular techniques, these extraordinary and virtually ... -
Cutaneous leishmaniasis in Uganda: report of the first case at Mulago National Referral and Teaching Hospital
(Intercontinental Journals, 2012)The transmission of Leishmania in central Uganda is little known despite that equine leishmaniasis was reported on the mainland in 1926. A case is reported of cutaneous leishmaniasis in an immunocompromised patient, possibly ... -
Emergence of sickle cell gene through migration and intermarriage: A case study
(Africa Journal of Animal and Biomedical Sciences, 2009)Sickle cell disease (SCD) is an inheritable disorder which is very common among persons of equatorial regions including Africa. The evolution of SCD is linked to malaria endemicity in which sickle cell traits are selected for ... -
Evaluation of capilia TB assay for rapid identification of mycobacterium tuberculosis complex in BACTEC MGIT 960 and BACTEC 9120 blood cultures
(BioMed Central, 2012)Background: Capilia TB is a simple immunochromatographic assay based on the detection of MPB64 antigen specifically secreted by the Mycobacterium tuberculosis complex (MTC). Capilia TB was evaluated for rapid identification ... -
Female genital tuberculosis in Uganda
(African Journal of Animal and Biomedical Sciences., 2008)A retrospective clinico-pathological study of 39 cases of female genital tuberculosis (FGTB) observed from 1976 – 1986 was conducted in the Department of Pathology, Medical School, Makerere University. The frequency of ... -
Genetic variations in ABCB1 and CYP3A5 as well as sex influence quinine disposition among Ugandans
(Lippincott Wilkins & Williams, 2010)Abstract: Quinine is one of the most effective antimalarial drugs, although its clinical use is limited as a result of its narrow safety margin. Quinine is a substrate of the polymorphic p-glycoprotein and CYP3A4/3A5. This ... -
HIV serostatus disclosure and lived experiences of adolescents at the Transition Clinic of the Infectious Diseases Clinic in Kampala, Uganda: a qualitative study
(Routledge, 2011)Most studies on HIV serostatus disclosure and adolescents focus on whether, how and when to disclose to adolescents their HIV diagnosis. Fewer studies have examined HIV serostatus disclosure by adolescents who know they ... -
HIV/AIDS patients display lower relative bioavailability of Efavirenz than healthy subjects
(Adis Data Information BV., 2011)Background: Pharmacokinetic studies of antiretroviral drugs are often conducted in adult healthy subjects, and the results are extrapolated to HIV/AIDS patients. HIV/AIDS, however, is known to cause morphological and ... -
In silico prediction of efavirenz and rifampicin drug–drug interaction considering weight and CYP2B6 phenotype
(The British Pharmacological Society, 2010)AIMS This study aimed to test whether a pharmacokinetic simulation model could extrapolate nonclinical drug data to predict human efavirenz exposure after single and continuous dosing as well as the effects of concomitant ... -
Inpatient mortality in children with clinically diagnosed malaria as compared with microscopically confirmed malaria
(Lippincott Wilkins & Williams, 2008)Background: Inpatient treatment for malaria without microscopic confirmation of the diagnosis occurs commonly in sub-Saharan Africa. Differences in mortality in children who are tested by microscopy for Plasmodium falciparum ... -
A meta‑analysis of telemedicine success in Africa
(2013-05)The use of information and communication technologies (ICT) tools to improve the efficiency of professionalism at work is increasing every time under the dynamic digital environment. Tools such as telemedicine, tele‑education, ... -
Nasopharyngeal carriage rate of Streptococcus pneumoniae in Ugandan children with sickle cell disease
(BioMed Central, 2012)Background: Nasopharyngeal carriage of Streptococcus pneumoniae is a determinant for invasive pneumococcal disease, which often complicates homozygous sickle cell disease. Here, we determined the nasopharyngeal carriage ... -
NeuroAIDS in Africa
(Informa Healthcare, 2010)In July 2009, the Center for Mental Health Research on AIDS at the National Institute of Mental Health organized and supported the meeting “NeuroAIDS in Africa.” This meeting was held in Cape Town, South Africa, and ... -
A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans
(The British Pharmacological Society, 2009)AIMS Efavirenz exhibits pharmacokinetic variability causing varied clinical response. The aim was to develop an integrated population pharmacokinetic/pharmacogenetic model and investigate the impact of genetic variations, ... -
A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans
(Wiley-Blackwell, 2009)AIMS Efavirenz exhibits pharmacokinetic variability causing varied clinical response. The aim was to develop an integrated population pharmacokinetic/pharmacogenetic model and investigate the impact of genetic variations, ... -
Plasma levels of DDT/DDE and liver function in malaria control personnel prior to DDT in-door residual spray in Northern Uganda, 2008
(African Journal of Animal and Biomedical Sciences, 2010)Where 20 million Ugandans are debilitated by malaria in a year, there is continued need of dichlorodiphenyltrichloroethane (DDT) for vector control while further research is implemented to clarify the health impact of ... -
Primary alveolar rhabdomyosarcoma of breast in a 13 year old female with cardiopulmonary metastases and cytohistological correlation: A case report
(Journal of Cancer Research & Therapy, 2013)Rhabdomyosarcoma is the commonest soft tissue sarcoma of childhood. The tumour commonly occurs in the body regions of the head and neck, genitourinary and extremities. Primary rhabdomyosarcoma of the breast is extremely ...