School of Bio-Medical Sciences (Bio-Medical)
Recent Submissions
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Evaluation of the effect of pim6 on the induction of hiv-1 expression from memory cd4+ t cells of virally suppressed hiv-1 patients attending TASO clinic, Mulago.
(Nakimuli Cynthia, 2020-01-07)Background: Latent HIV-1 reservoirs harbour human immunodeficiency virus type 1 (HIV-1) proviral DNA which can be reactivated to express viral RNA. Memory CD4+ T cells in HIV-infected persons are critical as HIV reservoirs, ... -
Monocyte activation and dysregulation in treated and untreated hiv-1 infected Ugandans.
(Makerere University, 2018-08-30)Introduction: Mechanism for increased non-AIDs co morbidities in HIV-1infected individuals on combinatorial antiretroviral therapy (cART) still requires exploration. This is majorly attributed to chronic monocyte activation ... -
Characterization of extended spectrum βlactamases elaborated in enterobacteriaceae in Uganda.
(Makerere University, 2017-08-23)Background: Extended spectrum β-lactamase producing Enterobacteriaceae (ESBL-PE) have been identified as a major cause of both community and facility associated infections and are closely linked to faecal carriage in the ... -
Perceptions, Knowledge and factors that Influence the Acceptability of Genetically Modified Foods in Kampala City
(Makerere university, 2019-08)Introduction: Food is one of the most important basic needs for the survival of all human beings. With the rapid growing population in the world, the molecular genetics has become a very important tool in the improvement ... -
Comparison of Ackers culture to Inpouch culture for the diagnosis of Trichomonas vaginalis among Symptomatic Females at Mulago Hospital
(Makerere university, 2015-10)Background: Trichomoniasis is the most curable sexually transmitted Infection (STI) in the world, caused by the genital Trichomonas vaginalis infection. The Trichomona vaginalis is a single celled flagellated eukaryote ... -
The challenge posed by lay catechists’ poverty to their effectiveness in evangelization in the light of redemptoris missio in Kasanga Parish, Kasese Catholic Diocese
(Makerere University, 2015-04)It is true the Bishop is primarily the agent of Evangelization; this becomes very vivid when he has a very good team of coworkers, like the priests, Nuns, religious brothers and Catechists. Right back from the early ... -
A molecular phylogenetic and modeling approach towards understanding the transmission dynamics and genetic diversity of HIV-1 in the fishing communities of Lake Victoriaa, Uganda
(Makerere University, 2019-11-29)Fishing communities (FCs) in Uganda have a greater HIV burden relative to other high-risk groups and the general population (GP). As a result of the very high HIV-1 incidence rates, they have been hypothesized to act ... -
Molecular Characterization of Uropathogenic Escherichia coli Isolates from Clients with Community-acquired Urinary Tract Infections Attending Outpatient Clinics in Kampala District
(Makerere University, 2019-08)Background: Community-acquired urinary tract infection (CA-UTI) commonly caused by uropathogenic Escherichia coli (UPEC) is mainly treated empirically but there is increased resistance to different common antimicrobial ... -
Phenotypic Diagnosis and Characterization of Fungaemia using Conventional Blood Culture
(Makerere university, 2019-08-01)Background: Fungaemia is highly associated with immunocompromised populations as a results of long hospital stays, intensive care unit admissions and oncology. Blood culture is the most reliable conventional method in the ... -
Effect of N-Acetyl cysteine on Moringa oleifera aqueous leaf extract-induced hepatotoxicity in Wistar Albino rats
(2019-12)Background: Moringa oleifera (M. oleifera) is a highly valued medicinal plant widely used to treat various ailments. It has a variety of nutritional and medicinal properties that are attributed to the various phytochemical ... -
VARIATIONS IN TRIM5α AND CYCLOPHILIN A GENES AMONG HIV-1 ELITE CONTROLLERS AND NON CONTROLLERS IN UGANDA
(Makerere University, 2019-12-10)Background: Human immunodeficiency virus type-1 (HIV-1) elite controllers represent a unique population that controls viral replication in the absence of antiretroviral therapy (ART). Various genetic, immunologic and ... -
E valuation of the Impact of HIV-1 Infections on Cytomegalovirus Specific T cells Responses
(Makerere University, 2019-10-30)Background: Incomplete understanding of the effect of HIV-1 infection on T cell immune response to HCMV is a barrier to development of better control strategies for HCMV infection in HIV-1 infected individuals. Depletion ... -
Compensatory mutations in rpoA, rpoC and rpoD genes among rifampicin-resistant Mycobacterium tuberculosis isolates from Uganda
(Makerere University, 2019-11-11)Background; Mycobacterium tuberculosis can acquire resistance to rifampicin through mutations in the rpoB gene. This is normally accompanied by the fitness cost which however can be mitigated by the acquired secondary ... -
Association of Carbapenemase Genes with Phenotypic Resistance to Carbapenems among Gram Negative Bacteria
(Winnie Binoga, 2019-12-05)BACKGROUND: Carbapenem drugs are the last resort antibacterial agents used in the treatment of Extended Spectrum Beta-Lactamase multi drug resistant Gram negative bacterial infections. Resistance to these drugs is reported ... -
INNATE IMMUNE SYSTEM RECOVERY AFTER LONG TERM ANTIRETROVIRAL THERAPY IN AN AFRICAN COHORT
(Makerere University, 2019-08-30)Background: Restoration of the immune system has been observed in many cohorts worldwide upon initiation of antiretroviral therapy. However, we have reported partial restoration of the T cell subset function despite seven ... -
PREVALENCE AND ASSOCIATED FACTORS FOR INTESTINAL PARASITIC INFECTIONS AMONG PRIMARY SCHOOL CHILDREN IN KARENGA SUBCOUNTY, KAABONG DISTRICT
(Makerere University, 2019-11-28)Background:Intestinal parasitic infections caused by helminths and protozoa are responsible for considerable morbidity throughout world. We did not know the burden of parasite infections in Karenga Sub county, Kaabong ... -
EVALUATION OF AN IN-HOUSE PROBE-BASED REAL-TIME PCR TEST FOR EARLY INFANT HIV-1 DIAGNOSIS IN UGANDA
(2019)Background: HIV infection remains a problem worldwide, with the majority of the cases being in resource-limited settings. Pediatric HIV testing is lagging with only 43 % of HIV-exposed infants being tested within the ... -
Maternal transfer of immunoglobulin-g (igg) sub-types and its association to immunity against plasmodium falciparum infection among children in a Ugandan birth cohort (Busia-Eastern Uganda)
(2019-11-04)Background: Children in malaria endemic area acquire maternal transferred immunity that is thought to be protective in their early months of life. Maternally transferred antibodies, mainly IgG play a critical role. IgG ... -
Significance of minority HIV-1 X-4-tropic variants, Host CCR5 promoter genotype in predicting paediatric Virological failure
(Makerere University, 2019-11-04)Background By Sept 2018, only 59.3% of all HIV positive children on cART under 5 years were achieving virological suppression compared to 88.4% in the general population in Uganda. However, while its known that a tropism ... -
Antimicrobial Susceptibility and Plasmid Genes Conferring Multi-Drug Resistance among Klebsiella Pneumoniae Isolated from patients attending Mulago National Referral Hospital from 2017 to 2018.
(Makerere University, 2019-11-25)Introduction: Antimicrobial Resistance results from exposure of microorganisms to antimicrobial substances, consequently with the ineffectiveness of treatments and exacerbating the risk of spread to others. Klebsiella ...
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