School of Bio-Medical Sciences (Bio-Medical)
Recent Submissions
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The microbiome in the blood of HAART-Naive HIV positive patients
(2018-11)Introduction: Infection with HIV results in the loss of gut mucosal CD4 T cells of the Th17 subtype responsible for maintaining integrity of the mucosa well as antimicrobial immunity. This results in an upset in the balance ... -
In vitro antifungal effect of combined extracts of Euphorbia hirta L. And Carica papaya L.
(2018)Trichophyton rubrum accounts for up to 69.5 % of all dermatophyte infections worldwide including ringworms (Tinea). High costs of treatment, drug resistance, side effects and increasing incidences of such fungal infections ... -
EVALUATION OF CD27 EXPRESSION AS A POTENTIAL BIOMARKER TO DISCRIMINATE ACTIVE FROM LATENT TUBERCULOSIS
(2017-11-16)There is no Gold standard test that can be used to differentiate Latent Tuberculosis Infection (LTBI) from Active Tuberculosis (ATB) with the current tests available. We investigate the use of CD27 expression on CD4 T cells ... -
Prevalence of phenotypic pyrazinamide resistance and agreement with PNCA mutations in mycobacterium tuberculosis isolated from the national drug resistance survey in Uganda, 2008-2011.
(Makerere University, 2018-12-06)Background: Pyrazinamide (PZA) is a pro-drug with high sterilizing effect used to treat both susceptible and multi-drug resistant tuberculosis. PZA susceptibility testing is not commonly done in Uganda because it is expensive ... -
Performance of the tuberculosis specimen referral system in the South Western TB zone of Uganda
(Makerere University, 2017-02)Background: Multidrug resistant tuberculosis (MDR-TB) stands at 12.5% in Uganda among the retreatment TB cases. In an effort to accelerate the WHO-recommended MDR-TB diagnosis and surveillance, the Uganda NTLP in 2008 ... -
BRCA1 and BRCA2 mutations in selected exons in breast cancer patients attending Mulago Hospital, Uganda
(Makerere University, 2017-02)Breast cancer 1 (BRCA1) and Breast cancer 2 (BRCA2), mutation recognition is crucial for cancer risk assessment, identification of suitable breast cancer treatments, and personalised breast cancer prophylaxis in mutation ... -
The sputum microbiome composition in pulmonary TB patients and its changes through TB treatment.
(Makerere University, 2018-12-02)Background: Commensal microbiota residing in or on the human body play key roles in maintaining health and immunity. The abundance and dynamics of these microbial communities when disrupted can result in dysbiosis and the ... -
Whole genome assembly and functional significance of nonsynonymous genetic variants of mycobacterium tuberculosis Uganda genotype isolated from Kampala, Uganda.
(Makerere University, 2018-12-06)Background: Mycobacterium tuberculosis complex (MTC) was initially regarded as a highly homogeneous population; however, recent data suggest the causative agents of tuberculosis are more genetically and functionally diverse ... -
Evaluation of mycobacterium tuberculosis thymidylate kinase as diagnostic biomarker for pulmonary tuberculosis among HIV positive individuals at mjap- iss clinic.
(2018-11-28)Background Tuberculosis (TB) is the leading cause of morbidity & mortality among HIV positive individuals. Diagnosis of TB in context of HIV co-infection remains challenging. Mycobacterium tuberculosis (M.tb) thymidylate ... -
Nk cell responses among hiv-1 sero negative most at risk individuals in Kampala district.
(Makerere University, 2018-10)With more than 30 years of the HIV-1 epidemic, development of an effective vaccine has faced several challenges including but not limited to determining the perfect animal model to predict the effectiveness of an HIV-1 ... -
EFFECT OF INTENSIVE VERSUS STANDARD ANTHELMINTHIC TREATMENT ON INNATE IMMUNE RESPONSES IN HIGH HELMINTH BURDEN UGANDAN FISHING VILLAGES
(Makerere University, 2018-11-22)Background: Mass drug administration (MDA) was one of the strategies set by the World Health Organization (2012), to eliminate helminths, reduce helminth-associated morbidity and mortality. Following MDA implementation, a ... -
PREVALENCE OF VIROLOGICAL SUPPRESSION AND PATTERNS OF ACQUIRED HIV DRUG RESISTANCE AMONG INDIVIDUALS ON FIRST-LINE ANTIRETROVIRAL THERAPY IN FISHERFOLK COMMUNITIES IN UGANDA
(2018-10-03)Background: The UNAIDS targets sustained viral suppression among at least 90% of HIV individuals on antiretroviral therapy (ART), yet viral load (VL) monitoring is rarely done in resource-limited settings due to high costs. ... -
Carbapenemase producing Enterobacterieceae carriage among health care workers in selected units of Mulago national referral hospital and Uganda heart institiute
(Makerere University, 2018-10)Background:Antimicrobial resistance is a global public health concern contributing to increased morbidity and mortality particularly in low income countries where infection control is often inadequate. Multidrug-resistant ... -
Knowledge, attitude and use of direction signs among patients and care givers within Mulago national referral hospital.
(Makerere University, 2018-05-07)Background Signage is a way of creating knowledge or awareness of where one is going prior to arrival. Signs are used in various environments such as large facilities, schools, roads etc. Before the existence of language, ... -
Effects of Mycobacterium tuberculosis on B cell responses.
(Makerere University, 2018-11-04)Background Mycobacterium tuberculosis (M.tb) causes tuberculosis (TB), the leading cause of death from a single pathogen. The success of this microbe has been linked to its subversive effects on host immunity. Indeed, ... -
Molecular Diversity of HIV-1 among Long Term Non-progressors attending MJAP-ISS clinic, Mulago
(Makerere University, 2018-11)Background: To date efforts are still being made to develop an efficacious and safe vaccine to stop the spread of Human Immunodeficiency Virus. Long term non-progressors (LTNPs); who harbour the virus but clinically show ... -
P53 protein expression in nephroblastoma and its association with different histological types and components as seen in the Department of Pathology, Makerere University Kampala, Uganda
(Makerere University, 2018-08)Background: Wilms’ tumour is one of the common solid tumours of childhood with an incidence of approximately 1 in 10,000 children. It is highly responsive to chemotherapy and carries overall good prognosis. However, 10 ... -
Knowledge, attitudes and practice of virtual patients technology among undergraduate students at Makerere University College of Health Sciences
(Makerere University, 2015-02)Background: Virtual Patient is an ―interactive computer simulation of real-life clinical scenarios for the purpose of medical training, education, or assessment‖. The technology has been used since 1971when the first ... -
Serum oestrogen, progesterone and prolactin profiling in mastalgia at Mulago Hospital Breast Clinic
(Makerere university, 2015-08)Background/Introduction: Approximately 60% to 70% of women experience some degree of breast pain at some stage of their lives. In Mulago Hospital, a cross sectional study conducted in 2005 on patients attending the breast ... -
Prevalence and factors associated with dry eye syndrome in adult patients presenting at Mulago Hospital
(Makerere University, 2015-09)Introduction: Dry eye syndrome is a disease of tears and ocular surface that results in symptoms of ocular discomfort and visual disturbance with potential to damage to the ocular surface. There is limited published ...
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