School of Bio-Medical Sciences (Bio-Medical)
Recent Submissions
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GENETIC VARIATIONS WITHIN THE CCR5 PROMOTER REGION AMONG ELITE AND VIREMIC CONTROLLERS IN UGANDA
(2019-11-13)Background: Mechanisms for HIV control among elite and viremic controllers are not fully understood. Although studies conducted in Uganda have reported the existence of these controllers, research has not yet sounded out ... -
DEVELOPMENT AND OPTIMIZATION OF AN IN VITRO METHOD TO FORCE AND SELECT FOR FUNCTIONAL HIV-1 INTERSUBTYPE pol RECOMBINANTS
(Makerere University, 2019-10-22)Introduction Inter subtype recombination in the pol gene of the HIV-1 affects the enzymatic structure and integrity which greatly impacts their function. These may be silent, deleterious or beneficial for the survival ... -
Nasopharyngeal co-colonization and drug resistance patterns of potentially pathogenic bacteria in children attending Mulago assessment centre Pediatric Unit of Mulago National Referral Hospital, Uganda
(Makerere University, 2019-10)Background: The human nasopharynx is colonized by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and Staphylococcus aureus. These bacteria may cause several diseases, especially in young children. ... -
Renal Lesions At Autopsy Among Adults At Mulago Hospital Over A Five Year Period (2009-2013)
(Makerere University, 2019)Introduction Autopsy is one of the techniques that can be utilized to study disease that didn’t present any suggestive features in life or that was not fully studied in life, and kidney diseases fall in those diseases ... -
AN ASSESSMENT OF UNDERSTANDING OF INFORMATION PROVIDED IN GENETIC RESEARCH AMONG PEOPLE LIVING WITH HIV AT THE INFECTIOUS DISEASES INSTITUTE (IDI)
(Makerere University, 2019-07)Introduction Obtaining informed consent is essential for biomedical research; and for informed consent to be valid, it is imperative that participants understand all the information disclosed to them before making voluntary ... -
Heme Oxygenase-1 and Neopterin Plasma Levels and their role in Distinguishing Active from Latent TB among HIV/TB Co-Infected Patients
(Makerere University, 2019-10-18)Background: Tuberculosis(TB) diagnosis in the presence of HIV co-infection remains challenging. Heme oxygenase 1(HO-1) and neopterin have shown to be as potential biomarkers for TB diagnosis. Infection of macrophages with ... -
Human B and T cell responses to novel Schistosoma mansoni skin-stage antigens
(2019-10)Background Larvae of Schistosoma (schistosomula) are highly susceptible to host immune responses and are attractive prophylactic vaccine targets. Despite this, cellular and humoral immune responses against schistosomula ... -
Functional host-genetic loci associated with pediatric HIV-disease progression in Uganda and Botswana.
(2019-10-07)Background: According to UNAIDS, HIV/AIDS remains a leading cause of morbidity and mortality in children under the age of 15. Distinct conditions of HIV-disease progression have been observed in different populations ... -
Evaluation of levels of T. cruzi ribosomal P protein homologous antigens and IgG antibodies among patients with Endomyocardial Fibrosis in Mulago Uganda
(Makerere University, 2017-11-22)Endomyocardial Fibrosis (EMF) is a chronic inflammatory disease of the heart whose cause is still unknown yet about 10 to 12 million people are affected worldwide. In Uganda EMF prevalence is about 10-20% of all the cardiac ... -
Establishment of a transformation and regeneration protocol for Uganda’s passion fruit using gus reporter gene
(Makerere university, 2014-10)Declining yields from passion fruit farming due to a number of problems ranging from pests, diseases, environmental stress, low yields, have initiated widespread enterprise abandonment by farmers. Crop improvement efforts ... -
Outcome and factors associated with mortality of neonates with surgical conditions at Mulago National Referral Hospital.
(Makerere University, 2015)Background: Surgery of neonates is a major challenge worldwide and especially in low and middle income countries where mortality due to surgical conditions has remained high. In developed countries, there has been remarkable ... -
The impact of traditional marriage on church marriage among the Acholi in Gulu Cathedral Parish, in the Light of Familiaris Consortio
(Makerere University, 2015-05)Among the Acholi marriage known as nyom is an heterosexual union of a man and a woman following the precepts of the Acholi culture to enable them be officially recognized as husband and wife. The venue for the Acholi ... -
The microbiome in the blood of HAART-Naive HIV positive patients
(2018-11)Introduction: Infection with HIV results in the loss of gut mucosal CD4 T cells of the Th17 subtype responsible for maintaining integrity of the mucosa well as antimicrobial immunity. This results in an upset in the balance ... -
In vitro antifungal effect of combined extracts of Euphorbia hirta L. And Carica papaya L.
(2018)Trichophyton rubrum accounts for up to 69.5 % of all dermatophyte infections worldwide including ringworms (Tinea). High costs of treatment, drug resistance, side effects and increasing incidences of such fungal infections ... -
EVALUATION OF CD27 EXPRESSION AS A POTENTIAL BIOMARKER TO DISCRIMINATE ACTIVE FROM LATENT TUBERCULOSIS
(2017-11-16)There is no Gold standard test that can be used to differentiate Latent Tuberculosis Infection (LTBI) from Active Tuberculosis (ATB) with the current tests available. We investigate the use of CD27 expression on CD4 T cells ... -
Prevalence of phenotypic pyrazinamide resistance and agreement with PNCA mutations in mycobacterium tuberculosis isolated from the national drug resistance survey in Uganda, 2008-2011.
(Makerere University, 2018-12-06)Background: Pyrazinamide (PZA) is a pro-drug with high sterilizing effect used to treat both susceptible and multi-drug resistant tuberculosis. PZA susceptibility testing is not commonly done in Uganda because it is expensive ... -
Performance of the tuberculosis specimen referral system in the South Western TB zone of Uganda
(Makerere University, 2017-02)Background: Multidrug resistant tuberculosis (MDR-TB) stands at 12.5% in Uganda among the retreatment TB cases. In an effort to accelerate the WHO-recommended MDR-TB diagnosis and surveillance, the Uganda NTLP in 2008 ... -
BRCA1 and BRCA2 mutations in selected exons in breast cancer patients attending Mulago Hospital, Uganda
(Makerere University, 2017-02)Breast cancer 1 (BRCA1) and Breast cancer 2 (BRCA2), mutation recognition is crucial for cancer risk assessment, identification of suitable breast cancer treatments, and personalised breast cancer prophylaxis in mutation ... -
The sputum microbiome composition in pulmonary TB patients and its changes through TB treatment.
(Makerere University, 2018-12-02)Background: Commensal microbiota residing in or on the human body play key roles in maintaining health and immunity. The abundance and dynamics of these microbial communities when disrupted can result in dysbiosis and the ... -
Whole genome assembly and functional significance of nonsynonymous genetic variants of mycobacterium tuberculosis Uganda genotype isolated from Kampala, Uganda.
(Makerere University, 2018-12-06)Background: Mycobacterium tuberculosis complex (MTC) was initially regarded as a highly homogeneous population; however, recent data suggest the causative agents of tuberculosis are more genetically and functionally diverse ...
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