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Evaluation of capilia TB assay for rapid identification of mycobacterium tuberculosis complex in BACTEC MGIT 960 and BACTEC 9120 blood cultures
(BioMed Central, 2012)
Background: Capilia TB is a simple immunochromatographic assay based on the detection of MPB64 antigen specifically secreted by the Mycobacterium tuberculosis complex (MTC). Capilia TB was evaluated for rapid identification ...
Factors associated with health seeking behaviour of pulmonary tuberculosis patients at Mulago National Referral Tuberculosis Treatment Centre.
(2002-06)
SETTING:
The study was carried out at Mulago National Referral Tuberculosis Treatment Centre, Kampala, Uganda, East Africa.
OBJECTIVE:
The study aimed at assessing factors associated with the health-seeking behavior of ...
Strain diversity of mycobacterium tuberculosis non-Uganda isolates from patients with pulmonary tuberculosis in Kawempe
(Makerere University, 2013-05)
Background: Tuberculosis is a major public health problem in peri-urban areas of Kampala and Uganda in general. To date there is inconclusive information about strain diversity of Mycobacterium tuberculosis of the non ...
Performance of the tuberculosis specimen referral system in the South Western TB zone of Uganda
(Makerere University, 2017-02)
Background: Multidrug resistant tuberculosis (MDR-TB) stands at 12.5% in Uganda among the retreatment TB cases. In an effort to accelerate the WHO-recommended MDR-TB diagnosis and surveillance, the Uganda NTLP in 2008 ...
Compensatory mutations in rpoA, rpoC and rpoD genes among rifampicin-resistant Mycobacterium tuberculosis isolates from Uganda
(Makerere University, 2019-11-11)
Background; Mycobacterium tuberculosis can acquire resistance to rifampicin through mutations in the rpoB gene. This is normally accompanied by the fitness cost which however can be mitigated by the acquired secondary ...
Detection of clinically relevant respiratory viruses and their temporal dynamics in sputum of tuberculosis patients on anti-TB drugs at Naguru Hospital, Kampala, Uganda
(Makerere University, 2024)
Background
Tuberculosis is one of the leading infectious causes of death in the world, with nearly 10 million new cases diagnosed each year, resulting into an estimated 1.3 million deaths(1). The relationship between M. ...
Mycobacterium tuberculosis associated immune activation, inhibition and exhaustion profiling to predict active tuberculosis disease among presumptive tuberculosis participants and monitor anti-tuberculosis treatment response.
(Makerere University, 2023)
Globally, tuberculosis (TB) is the leading cause of mortality and morbidity especially among resource-limited populations including Uganda. This statistic is greatly fueled by the delay in diagnosis of the disease and ...
Diagnostic accuracy of anti-mycobacterial protein 51 antibodies as a biomarker for latent TB infection in asymptomatic HIV positive individuals
(Makerere University, 2024)
Background: Tuberculosis (TB) continues to be a major global public health concern more so in sub-Saharan Africa and Uganda in particular due to inaccessibility to accurate, rapid and reliable diagnostic methods on top of ...
In vitro activity of mycobacteriophages against Mycobacterium tuberculosis biofilms
(Makerere University, 2021-03)
Tolerance of Mycobacterium tuberculosis to antibiotics has been associated with its tendency to grow in cell aggregates known as biofilms. These biofilms consist of layers of cells covered by a lipid-rich extracellular ...
Mycobacterium tuberculosis expression of Antigen 85B (Ag85B) in different culture conditions
(Makerere University, 2022-03)
Background: : Secretion of specific proteins by Mycobacterium tuberculosis contributes to pathogenesis and immune responses in tuberculosis disease yet the quantification of these secreted proteins in-vitro are poorly ...