Browsing Infectious Diseases Institute (IDI) by Author "Mayanja-Kizza, Harriet"
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Artemether-Lumefantrine combination therapy for treatment of uncomplicated malaria: The potential for complex interactions with antiretroviral drugs in HIV-infected individuals
Byakika-Kibwika, Pauline; Lamorde, Mohammed; Mayanja-Kizza, Harriet; Khoo, Saye; Merry, Concepta; Van geertruyden, Jean-Pierre (Malaria Research and Treatment, 2011-02-14)Treatment of malaria in HIV-infected individuals receiving antiretroviral therapy (ART) poses significant challenges. Artemether-lumefantrine (AL) is one of the artemisisnin-based combination therapies recommended for ... -
An Autopsy Study Describing Causes of Death and Comparing Clinico-Pathological Findings among Hospitalized Patients in Kampala, Uganda
Cox, Janneke A.; Lukande, Robert L.; Nelson, Ann M.; Mayanja-Kizza, Harriet; Colebunders, Robert; Van Marck, Eric; Manabe, Yukari C. (PLoS ONE, 2012-03-14)Background: Information on causes of death in HIV-infected patients in Sub-Saharan Africa is mainly derived from observational cohort and verbal autopsy studies. Autopsy is the gold standard to ascertain cause of death. ... -
Clinical spectrum, risk factors and outcome of immune reconstitution inflammatory syndrome in patients with tuberculosis-HIV coinfection
Worodria, William; Menten, Joris; Massinga-Loembe, Marguerite; Mazakpwe, Doreen; Bagenda, Danstan; Koole, Olivier; Mayanja-Kizza, Harriet; Kestens, Luc; Mugerwa, Roy; Reiss, Peter; Colebunders, Robert; The TB-IRIS study group (International Medical Press, 2012)BACKGROUND: Here, we aimed to determine the clinical spectrum, predictors and outcomes of paradoxical tuberculosis-immune reconstitution inflammatory syndrome (TB-IRIS) in a resource-limited setting. METHODS: In a ... -
Evaluation of Dynabeads and Cytospheres Compared With Flow Cytometry to Enumerate CD41 T Cells in HIV-Infected Ugandans on Antiretroviral Therapy
Lutwama, Fred; Serwadda, Ronnie; Mayanja-Kizza, Harriet; Shihab, Hasan M.; Ronald, Allan; Kamya, Moses R.; Thomas, David; Johnson, Elizabeth; Quinn, Thomas C.; Moore, Richard D.; Spacek, Lisa A. (Lippincott Williams & Wilkins., 2008-07-01)Background: Laboratory-based monitoring of antiretroviral therapy is essential but adds a significant cost to HIV care. The World Health Organization 2006 guidelines support the use of CD4 lymphocyte count (CD4) to define ... -
Lopinavir/ritonavir significantly influences pharmacokinetic exposure of artemether/lumefantrine in HIV-infected Ugandan adults
Byakika-Kibwika, Pauline; Lamorde, Mohammed; Okaba-Kayom, Violet; Mayanja-Kizza, Harriet; Katabira, Elly; Hanpithakpong, Warunee; Pakker, Nadine; Dorlo, Thomas P. C.; Tarning, Joel; Lindegardh, Niklas; de Vries, Peter J.; Back, David; Khoo, Saye; Merry, Concepta (Journal of Antimicrobial Chemotherapy, 2012-02-08)Background: Treatment of HIV/malaria-coinfected patients with antiretroviral therapy (ART) and artemisininbased combination therapy has potential for drug interactions. We investigated the pharmacokinetics of artemether, ... -
A new model to monitor the virological efficacy of antiretroviral treatment in resource-poor countries
Colebunders, Robert; Laurence, John; Shihab, Hasan M.; Semitala, Fred; Lutwama, Fred; Bakeera-Kitaka, Sabrina; Lynen, Lut; Spacek, Lisa; Reynolds, Steven J.; Quinn, Thomas C.; Viner, Brant; Mayanja-Kizza, Harriet; Kamya, Moses, R. (Elsevier, 2006)Monitoring the efficacy of antiretroviral treatment in developing countries is difficult because these countries have few laboratory facilities to test viral load and drug resistance. Those that exist are faced with a ... -
Outcomes of cryptococcal meningitis in Uganda before and after the availability of highly active antiretroviral therapy
Kambugu, Andrew; Meya, David B.; Rhein, Joshua; O’Brien, Meagan; Janoff, Edward N.; Ronald, Allan R.; Kamya, Moses R.; Mayanja-Kizza, Harriet; Sande, Merle A.; Bohjanen, Paul R.; Boulware, David R. (CID, 2008)Background. Cryptococcal meningitis (CM) is the proximate cause of death in 20%–30% of persons with acquired immunodeficiency syndrome in Africa. Methods. Two prospective, observational cohorts enrolled human immunodeficiency ... -
Pharmacokinetics and pharmacodynamics of intravenous artesunate during severe malaria treatment in Ugandan adults
Byakika-Kibwika, Pauline; Lamorde, Mohammed; Mayito, Jonathan; Nabukeera, Lillian; Mayanja-Kizza, Harriet; Katabira, Elly; Hanpithakpong, Warunee; Obua, Celestino; Pakker, Nadine; Lindegardh, Niklas; Tarning, Joel; de Vries, Peter J.; Merry, Concepta (BioMed Central, 2012-04-27)Background: Severe malaria is a medical emergency with high mortality. Prompt achievement of therapeutic concentrations of highly effective anti-malarial drugs reduces the risk of death. The aim of this study was to assess ... -
Point-of-care lactate testing predicts mortality of severe sepsis in a predominantly HIV type 1–infected patient population in Uganda
Moore, Christopher C.; Jacob, Shevin T.; Pinkerton, Relana; Meya, David B.; Mayanja-Kizza, Harriet; Reynolds, Steven J.; Scheld, W. Michael (Infectious Diseases Society of America, 2008)Background: Prediction of mortality may improve management and outcomes of patients with sepsis in resource-limited settings. Therefore, we evaluated the ability of a hand-held portable whole-blood lactate (PWBL) analyzer ... -
Resurrecting the triple threat: academic social responsibility in the context of global health research
Manabe, Yukari C; Jacob, Shevin T; Thomas, David; Quinn, Thomas C.; Ronald, Allan; Coutinho, Alex; Mayanja-Kizza, Harriet; Merry, Concepta (CID, 2009-05-15)As a result of the pandemic of human immunodeficiency virus infection, more academic physicians involved in research are working in resource-limited settings, especially in the field of infectious diseases. These researchers ... -
Significant pharmacokinetic interactions between artemether/lumefantrine and efavirenz or nevirapine in HIV-infected Ugandan adults
Byakika-Kibwika, Pauline; Lamorde, Mohammed; Mayito, Jonathan; Nabukeera, Lillian; Namakula, Rhoda; Mayanja-Kizza, Harriet; Katabira, Elly; Ntale, Muhammad; Pakker, Nadine; Ryan, Mairin; Hanpithakpong, Warunee; Tarning, Joel; Lindegardh, Niklas; Khoo, Saye; Back, David; Merry, Concepta (Oxford University Press, 2012)Objectives: Co-administration of artemether/lumefantrine with antiretroviral therapy has potential for pharmacokinetic drug interactions. We investigated drug–drug interactions between artemether/lumefantrine and efavirenz ... -
Treatment of severe sepsis with Artemether-Lumefantrine Is associated with decreased mortality in Ugandan patients without malaria
Moore, Christopher C; Jacob, Shevin T; Pinkerton, Relana; Banura, Patrick; Meya, David B; Reynolds, Steven J; Kenya-Mugisha, Nathan; Mayanja-Kizza, Harriet; Scheld, Michael. W (The American Society of Tropical Medicine and Hygiene, 2009)We enrolled 382 patients at two hospitals in Uganda in a prospective observational study of severe sepsis. Because artemisinins improve survival in murine sepsis models, we performed a post hoc analysis of the association ... -
Treatment of severe sepsis with Artemether-Lumefantrine Is associated with decreased mortality in Ugandan patients without malaria
Moore, Christopher C; Jacob, Shevin T; Pinkerton, Relana; Banura, Patrick; Meya, David B; Reynolds, Steven J; Kenya-Mugisha, Nathan; Mayanja-Kizza, Harriet; Scheld, Michael. W (American Society of Tropical Medicine and Hygiene, 2009)We enrolled 382 patients at two hospitals in Uganda in a prospective observational study of severe sepsis. Because artemisinins improve survival in murine sepsis models, we performed a post hoc analysis of the association ... -
Update on the efficacy, effectiveness and safety of artemether–lumefantrine combination therapy for treatment of uncomplicated malaria
Byakika-Kibwika, Pauline; Lamorde, Mohammed; Mayanja-Kizza, Harriet; Merry, Concepta; Colebunders, Bob; Van Geertruyden, Jean-Pierre (Dove Medical Press, 2009)Artemether–lumefantrine is one of the artemisisnin-based combination therapies recommended for treatment of uncomplicated falciparum malaria. The drug combination is highly efficacious against sensitive and multidrug ... -
Update on the efficacy, effectiveness and safety of artemether–lumefantrine combination therapy for treatment of uncomplicated malaria
Byakika-Kibwika, Pauline; Lamorde, Mohammed; Mayanja-Kizza, Harriet; Merry, Concepta; Colebunders, Bob; van Geertruyden, Jean-Pierre (Dove Medical Press, 2009-12-16)Artemether–lumefantrine is one of the artemisisnin-based combination therapies recommended for treatment of uncomplicated falciparum malaria. The drug combination is highly efficacious against sensitive and multidrug ... -
Update on the efficacy, effectiveness and safety of artemether–lumefantrine combination therapy for treatment of uncomplicated malaria
Byakika-Kibwika, Pauline; Lamorde, Mohammed; Mayanja-Kizza, Harriet; Merry, Concepta; Colebunders, Bob; Van Geertruyden, Jean-Pierre (Dove Medical Press, 2009)Artemether–lumefantrine is one of the artemisisnin-based combination therapies recommended for treatment of uncomplicated falciparum malaria. The drug combination is highly efficacious against sensitive and multidrug ...