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Performance of the tuberculosis specimen referral system in the South Western TB zone of Uganda
(Makerere University, 2017-02)
Background: Multidrug resistant tuberculosis (MDR-TB) stands at 12.5% in Uganda among the retreatment TB cases. In an effort to accelerate the WHO-recommended MDR-TB diagnosis and surveillance, the Uganda NTLP in 2008 ...
The clinical, radiological and laboratory features of tuberculosis in children at Mulago Hospital.
(2002)
The incidence of tuberculosis (TB) In Uganda is 150-200/100,000 of the population and an estimated incidence of smear positive adult cases of > 110/100,000 of the population. About a half of the ugandan population was ...
Effect of vitamin d binding protein gene polymorphisms and vitamin d bioavailability on cathelicidin expression in tuberculosis infection and disease
(Makerere University, 2023-01)
Background: The human antimicrobial peptide cathelicidin (LL-37) is involved in host innate immunity by the after activation of Toll-like receptors (TLRs), resulting in direct killing of Mycobacterium tuberculosis (MTB). ...
Effect of COVID-19 period on tuberculosis treatment success; A mixed methods study among tuberculosis patients at Jinja Regional Referral Hospital
(Makerere University, 2022-01)
Introduction: Before the COVID-19 pandemic, over 4000 people were dying from TB every day. TB is still a major public health threat globally, but the TB epidemic may be exacerbated by the COVID-19 pandemic. The lockdown ...
Rhomboids of mycobacteria: insight from phylogeny, genomic and complementation analysis.
(Makerere University, 2014)
Background
The rhomboid superfamily of proteins includes novel trans-membrane Serine-proteases that occur in all life-kingdoms, and are responsible for vital roles such as signaling in Drosophila, red blood cell invasion ...
Mycobacterium tuberculosis expression of Antigen 85B (Ag85B) in different culture conditions
(Makerere University, 2022-03)
Background: : Secretion of specific proteins by Mycobacterium tuberculosis contributes to pathogenesis and immune responses in tuberculosis disease yet the quantification of these secreted proteins in-vitro are poorly ...
Comparison of models for analysis of time to loss to follow up and associated risk factors among patients receiving tuberculosis treatment from Mbarara Regional Referral Hospital, Uganda
(Makerere University, 2023)
Background: Tuberculosis (TB) remains the top infectious killer worldwide. In Uganda, incidence of TB was reported at 200 per 100,000 people per year. Loss to follow up (LTFU) on TB treatment was 13% in Uganda and 10% in ...
Performance evaluation of the Uganda National Algorithm for Diagnosis of tuberculosis in children at Mulago National Referral Hospital-Kampala, Uganda
(Makerere University, 2023)
Background
Diagnosing childhood tuberculosis (TB) is a challenge, this led the Uganda national tuberculosis control program (NTLP) to develop a clinical treatment decision algorithm for children. However, there is limited ...
Uptake of isoniazid preventive therapy and associated factors among eligible people living with HIV/AIDS in care at health facilities in Tororo District
(Makerere University, 2023)
Introduction and Background: Uganda adopted the strategy of uptake of IPT among PLWHA. The aim of this was to reduce the risk of acquiring active TB among patients with latent TB infections. Despite various interventions, ...
Adoption of eHealth for community monitoring of TB/HIV services and its predictors among staff of Non-Government Organizations in Kampala, Uganda
(Makerere University, 2023)
Background: The use of electronic data capture and digital health technologies can greatly improve patient healthcare outcomes, through augmenting diagnosis, prescription and treatment, and patient-centered care. The global ...