Browsing School of Bio-Medical Sciences (Bio-Medical) by Type
Now showing items 21-28 of 28
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Programmed cell death in neurodegenerative brain disease
(2008)Death of brain cells by either apoptosis or necrosis is the hall mark of the pathology of most brain infections such as Alzheimer’s disease and AIDS dementia. The death of astrocytes in association with brain tumours appears ... -
Quantitative assessment of the sensitivity of various commercial reverse transcriptases based on armored HIV RNA
(Public Library of Science, 2010)Background: The in-vitro reverse transcription of RNA to its complementary DNA, catalyzed by the enzyme reverse transcriptase, is the most fundamental step in the quantitative RNA detection in genomic studies. As such, ... -
The reliability of sickling and solubility tests and peripheral blood film method for sickle cell disease screening at dictrict health centers in Uganda
(Clinics in Mother and Child Health, 2010)Although sickling and solubility tests and peripheral blood film methods are today available for sickle cell disease screening in Uganda, their reliability and ease of applicability have not been determined. This study was ... -
Smart, nano-engineered drug (NRTI)-immune conjugates for targeting HIV within reservoirs
(BioMed Central, 2011-07-22)Background: Infection with HIV, which culminates in the establishment of a latent proviral reservoir, presents formidable challenges for ultimate cure. Building on the hypothesis that ex-vivo or even in-vivo abolition or ... -
Substandard rifampicin based anti-tuberculosis drugs common in Ugandan drug market
(Journal Of Pharmacy And Pharmacological Research, 2013)Background: Tuberculosis (TB) is an important curable infectious disease in Uganda; its treatment however is facing a challenge of increasing drug resistance. Although Rifampicin containing Fixed-Dose Combination (R-FDC) ... -
An up-date on the prevalence of sickle cell trait in Eastern and Western Uganda.
(BioMed Central, 2010)Background: The first survey on sickle cell disease (SCD) done in Uganda in 1949, reported the district of Bundibugyo in Western Uganda to have the highest sickle cell trait (SCT) prevalence (45%). This is believed to be ... -
Use of hormonal contraceptives and risk of HIV-1 transmission: a prospective cohort study
(Elsevier, 2012-01-01)Background Hormonal contraceptives are used widely but their eff ects on HIV-1 risk are unclear. We aimed to assess the association between hormonal contraceptive use and risk of HIV-1 acquisition by women and HIV-1 ... -
Zinc adjunct therapy reduces case fatality in severe childhood pneumonia: a randomized double blind placebo-controlled trial
(BioMed Central, 2012)Background: Pneumonia is a leading cause of children’s deaths in developing countries and hinders achievement of the fourth Millennium Development Goal. This goal aims to reduce the under-five mortality rate, by two thirds, ...