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Reverse vaccinology and molecular docking as tools to identify potential vaccine candidates against drug-resistant Mycobacterium tuberculosis and Mycobacterium bovis
(Makerere University, 2022-03-29)
The emergence of multi-drug-resistant Mycobacterium tuberculosis (M.tb) and Mycobacterium bovis (M.bovis), the causative agents of Tuberculosis (TB) and zoonotic TB respectively are of significant threat to public health. ...
Insights into genomic variations between Mycobacterium tuberculosis compartmentalized in the lungs and blood of HIV-infected individuals in Uganda
(Makerere University, 2022-08-19)
Introduction: Mycobacterium tuberculosis (MTB), particularly clinical strains present a
genomic diversity that ranges from several single nucleotide polymorphisms (SNPs) to insertions
and deletions (INDELS). This study ...
Insights into genomic variations between Mycobacterium tuberculosis compartmentalized in the lungs and blood of HIV-infected individuals in Uganda
(Makerere University, 2022)
Introduction: Mycobacterium tuberculosis (MTB), particularly clinical strains present a genomic diversity that ranges from several single nucleotide polymorphisms (SNPs) to insertions and deletions (INDELS). This study ...
In vitro activity of mycobacteriophages against Mycobacterium tuberculosis biofilms
(Makerere University, 2021-03)
Tolerance of Mycobacterium tuberculosis to antibiotics has been associated with its tendency to grow in cell aggregates known as biofilms. These biofilms consist of layers of cells covered by a lipid-rich extracellular ...
Effect of vitamin d binding protein gene polymorphisms and vitamin d bioavailability on cathelicidin expression in tuberculosis infection and disease
(Makerere University, 2023-01)
Background: The human antimicrobial peptide cathelicidin (LL-37) is involved in host innate immunity by the after activation of Toll-like receptors (TLRs), resulting in direct killing of Mycobacterium tuberculosis (MTB). ...
Patient single nucleotide polymorphisms assiocated with Mycobacterium tuberculosis genotypes in Ugandan population
(Makerere University, 2022-12)
Uganda is one of the 30 World Health Organization-designated countries with a high burden of TB/HIV, with three main dominant genotypes that cause tuberculosis. Recent studies have shown that the M. tuberculosis Uganda ...
Diagnostic accuracy of mycobacterium tuberculosis DNA as detected by the top assay among the individuals with paucibillary TB
(Makerere University, 2023-11)
Background: One of the major reasons leading to the increased incidence of TB is the lack of a diagnostic with high sensitivity that can be relied on to capture even patients with low burden TB. This had been attempted by ...
Detection of clinically relevant respiratory viruses and their temporal dynamics in sputum of tuberculosis patients on anti-TB drugs at Naguru Hospital, Kampala, Uganda
(Makerere University, 2024)
Background
Tuberculosis is one of the leading infectious causes of death in the world, with nearly 10 million new cases diagnosed each year, resulting into an estimated 1.3 million deaths(1). The relationship between M. ...