School of Bio-Medical Sciences (Bio-Medical): Recent submissions
Now showing items 141-160 of 418
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Morphometric variations of the pterion among skulls at the Galloway Osteological Collection in the Department of Human Anatomy Makerere University
(Makerere University, 2022-12-15)Background: The pterion is an important anatomical land mark in neuro surgery, it’s also important in Forensic examination of the human skull, to anatomists when teaching undergraduate medical students and postgraduates ... -
Evaluation of safety profiles and effect on glucose tolerance of different parts of Rhus vulgaris meikle, a medicinal plant used in the traditional management of Type II Diabetes Mellitus in Uganda
(Makerere University, 2022-12-15)Background: Indigenous management of diabetes mellitus is common but not fully explored. Objective: The study determined and compared the hypoglycemic activities of root bark and leaf extracts of R. vulgaris in high glucose ... -
Mycobacterium tuberculosis expression of Antigen 85B (Ag85B) in different culture conditions
(Makerere University, 2022-03)Background: : Secretion of specific proteins by Mycobacterium tuberculosis contributes to pathogenesis and immune responses in tuberculosis disease yet the quantification of these secreted proteins in-vitro are poorly ... -
Early cytokine profiles associated with mild and asymptomatic COVID-19 disease severity in Uganda
(Makerere University, 2022-12-20)Emergence of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) constituted a global health threat of highly impactful and pandemic proportions. However, low COVID-19 disease severity was observed in Uganda ... -
Metagenomic analysis of coronaviruses in bat fecal matter collected from a human-bat interface around Arua City, West Nile Region, Uganda
(Makerere University, 2022-10)Background Many recent disease outbreaks in humans had a zoonotic virus etiology. The ongoing coronavirus disease 2019 (COVID-19) pandemic has had devastating health and socioeconomic impacts. Bats are reservoirs for a ... -
Utility of urine LAM Biomarker for treatment response monitoring during 8 weeks of MDR-TB treatment at Mulago National Referral Hospital
(Makerere University, 2022-03)Background: The current methods used in monitoring treatment response among MDR - TB patients have low sensitivity, take long to give results, are expensive and require BSL3 facilities. It is known that MTB LAM as a biomarker ... -
Use of natural killer cell based assays to assess response to isoniazid preventive therapy among Type 2 Diabetes patients with latent tuberculosis
(Makerere University, 2022-12)Background: Despite the presence of latent tuberculosis treatment such as Isoniazid treatment therapy, a quarter of the global population remains latently infected with the numbers expected to increase. There is also an ... -
Genetic Diversity of Bundibugyo ebolavirus from Uganda and the Democratic Republic of Congo
(Makerere University, 2022-01-02)Background The Ebola virus is one of the deadliest known viral pathogens. It was first discovered in 1976 during two consecutive outbreaks in the Democratic Republic of Congo (DRC) and Sudan. Since then six known strains ... -
Effect of baseline immune status on the antibody responses to Hepatitis B vaccination among adults
(Makerere University, 2022-11-30)Background; Hepatitis B virus (HBV) causes vaccine-preventable Hepatitis B disease. However, the immune response to the Hepatitis B vaccine varies, and 5 – 15% of vaccine recipients do not produce sufficient antibodies. ... -
Metabolic syndrome among HIV positive patients on antiretroviral therapy attending the art clinic at Fortportal Regional Referral Hospital
(2022-10-18)ABSTRACT Introduction The continuing evolution of potent antiretroviral therapy (ART) has resulted in dramatic reductions in HIV-associated morbidity and mortality. However, the availability of newer ART regimes has ... -
Predicting major depressive disorder among adults Living with HIV In Uganda: An Artificial Intelligence Approach
(Makerere University, 2022-08-01)Background Major depressive disorder is a leading cause of disability worldwide and a major contributor to the overall global burden of disease. The biggest percentage of the MDD burden pertains to low- and middle-income ... -
Using Gene and miRNA expression profiles in Breast cancer risk prediction : a machine learning-based approach
(Makerere University, 2022)Breast cancer (BC) incidence is commonly accompanied by poor treatment outcomes due to late diagnosis. BC risk prediction is important for timely diagnosis but it’s clinical utility is limited by high risk bias. Genetic ... -
T cell Expression of CD153 in Latent Tuberculosis Infection and Type 2 Diabetes Mellitus
(Makerere University, 2022-06-22)The increasing prevalence of latent tuberculosis among individuals with type 2 diabetes mellitus has increased the public health importance of TB and non-communicable diseases, yet the immune correlates of protection or ... -
Insights into genomic variations between Mycobacterium tuberculosis compartmentalized in the lungs and blood of HIV-infected individuals in Uganda
(Makerere University, 2022)Introduction: Mycobacterium tuberculosis (MTB), particularly clinical strains present a genomic diversity that ranges from several single nucleotide polymorphisms (SNPs) to insertions and deletions (INDELS). This study ... -
Effect of aqueous extracts of Moringa oleifera leaves on serum C-peptide levels in alloxan mono-hydrate induced diabetic wistar albino rats
(Makerere University, 2022-01-28)ABSTRACT Background: Moringa oleifera is rich in phytochemicals, and in Uganda, its leaves, roots and seeds are widely consumed for self-medication by patients affected by diabetes mellitus, hypertension, HIV/AIDS and ... -
Reverse vaccinology and molecular docking as tools to identify potential vaccine candidates against drug-resistant Mycobacterium tuberculosis and Mycobacterium bovis
(Makerere University, 2022-03-29)The emergence of multi-drug-resistant Mycobacterium tuberculosis (M.tb) and Mycobacterium bovis (M.bovis), the causative agents of Tuberculosis (TB) and zoonotic TB respectively are of significant threat to public health. ... -
Characterizing the composition of the airway microbiota of patients with COPD in a rural setting in Uganda using shotgun metagenomics, a case control study
(Makerere university, 2022-10-25)Introduction: Diverse airway microbiota play an important role in the development and integrity of the immune system that limits growth of pathogenic microorganisms and clearing bacterial infections. Community shifts from ... -
Breast Cancer Molecular Subtype Prevalence and Commonly Mutated Genes in Triple Negative Breast Cancer in Uganda
(Makerere University, 2022-11-25)Breast cancer is the second commonest cancer in women in Uganda, accounting for about 21% of all cancer related mortality in women in Uganda. An estimated 35-36% of all breast cancer patients in Uganda have triple negative ... -
Autopsy survey of histopathological features and immunohistochemical markers of dementia in medico-legal deaths at Mulago hospital and KCCA mortuaries, Uganda
(Makerere University, 2022-11-22)Background: Dementia is a neurodegenerative disorder characterized by an irreversible cognitive decline. Although previously associated with old age, in people aged 65 and above, recent studies have reported early-onset ... -
Unravelling the genetic risk associated with major depressive disorder among an ethnically diverse African ancestry population
(Makerere University, 2022-03)Major depressive disorder (MDD), which is a significant contributor to the global health burden is characterised by a pervasive low mood and an inability to feel pleasure in normally pleasurable activities. Most MDD genetic ...